Clinical Application of Double Ovulation Stimulation in Patients with Diminished Ovarian Reserve and Asynchronous Follicular Development Undergoing Assisted Reproduction Technology  

作　　者：Yi-zhuo YANG Ming ZHANG Sha MU Xin-meng Guo Hui WANG Zhe TANG Hong-mei PENG 

机构地区：[1]Department of Obstetrics and Gynecology,First Medical Center of the Chinese People’s Liberation Army General Hospital,Beijing,100853,China [2]College of Medicine,Nankai University,Tianjin,300071,China

出　　处：《Current Medical Science》2023年第2期304-312,共9页当代医学科学（英文）

基　　金：supported by a Chinese Military family planning project grant(No.17JS014).

摘　　要：Objective This study aimed to compare the clinical effects of double ovulation stimulation(DouStim)applied during the follicular and luteal phases with the antagonist protocol in patients with diminished ovarian reserve(DOR)and asynchronous follicular development undergoing assisted reproductive technology(ART).Methods The clinical data of patients with DOR and asynchronous follicular development receiving ART from January 2020 to December 2021 were retrospectively analyzed.The patients were divided into two groups according to their ovulation stimulation protocol:DouStim group(n=30)and antagonist group(n=62).Assisted reproduction and clinical pregnancy outcomes were compared between the two groups.Results In the DouStim group,the number of oocytes retrieved,metaphase II(MII)oocytes,two-pronuclei(2PN),day 3(D3)embryos,D3 high-quality embryos as well as blastocyst formation,implantation,and human chorionic gonadotropin-positive rates were significantly greater than those in the antagonist group(all P<0.05).No significant differences were found in MII,fertilization,or continued pregnancy rates at the first frozen embryo transfer(FET),in-vitro fertilization(IVF)cancellation,or early medical abortion rates between the groups(all P>0.05).Except for the early medical abortion rate,the DouStim group generally had favorable outcomes.In the DouStim group,the dosage and duration of gonadotropin and the fertilization rate were significantly greater in the first ovulation stimulation induction than in the second ovulation stimulation induction(P<0.05).Conclusion The DouStim protocol efficiently and economically obtained more mature oocytes and high-quality embryos for patients with DOR and asynchronous follicular development.

关 键 词：diminished ovarian reserve double ovulation stimulation follicular phase stimulation luteal phase stimulation 

分 类 号：R71[医药卫生—妇产科学]