Donor-Derived Transmission of Scedosporiosis in Kidney Transplant Recipients from a Systemic lupus erythematosus donor  

作　　者：Cheng ZENG Yong-sheng MA Jun-ying ZHOU Cheng-biao XUE Yan XIONG Wei ZHOU Li-hua ZHOU Jian-guo LI Shao-jun YE Qi-fa YE 

机构地区：[1]Zhongnan Hospital of Wuhan University,Institute of Hepatobiliary Diseases of Wuhan University,Transplant Center of Wuhan University,National Quality Control Center for Donated Organ Procurement,Hubei Key Laboratory of Medical Technology on Transplantation,Hubei Clinical Research Center for Natural Polymer Biological Liver,Hubei Engineering Center of Natural Polymer-based Medical Materials,Wuhan,430071,China [2]Department of Laboratory Medicine,Zhongnan Hospital of Wuhan University,Wuhan,430071,China [3]Intensive Care Unit,Zhongnan Hospital of Wuhan University,Wuhan,430071,China [4]The Third Xiangya Hospital of Central South University,Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology,Changsha,410013,China

出　　处：《Current Medical Science》2023年第2期417-420,共4页当代医学科学（英文）

基　　金：supported by National Key Clinical Specialty Construction Project(General Surgery).

摘　　要：Donor-derived infection(DDI)associated with Scedosporium spp is extremely rare,and results in a very poor prognosis.The present study reports a probable DDI due to Scedosporium boydii(S.boydii)from a donor with neuropsychiatric systemic lupus erythematosus.Two recipients developed Scedosporiosis after kidney transplantation from the same donor.Recipient 1 died of central nervous system infection due to S.boydii based on the clinical presentations,and the positive metagenomic next-generation sequencing(mNGS)and culture results for the cerebrospinal fluid.The other recipient with urinary tract obstruction due to S.boydii,which was identified through the positive culture and mNGS results of the removed stents,was successfully treated by stent replacement and voriconazole administration.Undiagnosed disseminated donor infection and the transmission of S.boydii should be given attention,particularly when the donor and recipients have primary immunodeficiency disease.The screening of donors and recipients for S.boydii using mNGS may be helpful in guiding antifungal prophylaxis and treatment recipients,due to its higher sensitivity and shorter diagnostic time relative to other traditional techniques.

关 键 词：kidney transplant Scedosporium boydii fungal infection donor-derived infection 

分 类 号：R593.241[医药卫生—内科学]