Crank up the volume:Osmotic stress induces WNK1 phase separation  

作　　者：Ji-Ung Jung Clinton A.Taylor IV Melanie H.Cobb 

机构地区：[1]Department of Pharmacology,UT Southwestern Medical Center,Dallas,TX,USA [2]These authors contributed equally:Ji-Ung Jung,Clinton A.Taylor IV

出　　处：《Cell Research》2023年第4期265-266,共2页细胞研究（英文版）

基　　金：Relevant research from the authors’lab was funded by grant I1243(to M.H.C.)from the Welch Foundation.

摘　　要：Cell shrinkage,which occurs in a hypertonic environment,results in a rapid rebound response to restore cell volume and ion concentrations.In a recent study published in Cell,BoydShiwarski et al.identify WNK1,a known homeostatic regulator of cell volume,as a molecular crowding sensor,and demonstrate how WNK1 contributes to cell volume recovery through cell shrinkage-dependent phase separation.

关 键 词：WNK1 SEPARATION SEPARATION 

分 类 号：Q2[生物学—细胞生物学]