Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence  

作　　者：Xinyu Jia Zhiling Pan Yang Yuan Bingnan Luo Yongbo Luo Sunandan Mukherjee Guowen Jia Liu Liu Xiaobin Ling Xiting Yang Zhichao Miao Xiawei Wei Janusz M.Bujnicki Kelei Zhao Zhaoming Su 

机构地区：[1]The State Key Laboratory of Biotherapy,Department of Geriatrics and National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University,Chengdu,Sichuan,China [2]Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province,School of Pharmacy,Chengdu University,Chengdu,Sichuan,China [3]Laboratory of Bioinformatics and Protein Engineering,International Institute of Molecular and Cell Biology in Warsaw,ul.Ks.Trojdena 4,PL-02-109,Warsaw,Poland [4]Department of Conservative Dentistry and Endodontics,West China Hospital of Stomatology,Sichuan University,Chengdu,Sichuan,China [5]Guangzhou Laboratory,Guangzhou International Bio Island,Guangzhou,Guangdong,China

出　　处：《Cell Research》2023年第4期328-330,共3页细胞研究（英文版）

基　　金：supported by the Ministry of Science and Technology of China(2022YFC2303700 and 2021YFA1301900 to Z.S.);the National Natural Science Foundation of China(32222040 and 32070049 to Z.S.,31970131 to K.Z.);Sichuan University start-up funding(20822041D4057 to Z.S.);J.M.B.and S.M.were supported by the Polish National Science Center(NCN 2017/26/A/NZ1/01083 and NCN 2021/43/D/NZ1/03360,respectively);Computational resources for SimRNA simulations were provided by the PoznańSupercomputing and Networking Center at the Institute of Bioorganic Chemistry,Polish Academy of Sciences through the Polish Grid Infrastructure(grant:plgsimcryox).Z.M.was supported by R&D program of Guangzhou Laboratory(SRPG22-003).

摘　　要：Dear Editor,Pseudomonas aeruginosa is a ubiquitous Gram-negative opportunistic bacterium that notoriously causes infections with a high mortality rate in hospitalized patients,especially those with compromised immune systems.P.aeruginosa can cause acute infections that are typically associated with the cytotoxins secreted by the type Ⅲ secretion system(T3ss).

关 键 词：RSM typically 

分 类 号：Q55[生物学—生物化学]