The Evolution of Iron-Related Comorbidities and Hospitalization in Patients with Hemochromatosis:An Analysis of the Nationwide Inpatient Sample  

作　　者：Ahmad Abou Yassine Kira MacDougall Roula Sasso Youssef Shammaa Mira Alsheikh Mohammad Abureesh Loai Dahabra Mohammad Alshami Stephen Mulrooney 

机构地区：[1]Department of Internal Medicine,Zucker School of Medicine at Hofstra/Northwell at Staten Island University Hospital,New York,NY,USA [2]Department of Gastroenterology,Zucker School of Medicine at Hofstra/Northwell at Staten Island University Hospital,New York,NY,USA

出　　处：《Blood Science》2023年第2期131-135,共5页血液科学（英文）

摘　　要：Hemochromatosis,either hereditary hemochromatosis(HH)or secondary hemochromatosis,consists of the accumulation of iron in the liver,heart,and other organs.It leads to end-organ damage in a proportion of affected subjects.Although liver-related morbidity(cirrhosis and hepatocellular carcinoma[HCC])and mortality are well established,the frequency of these complications remains controversial.The aim of this study is to examine the rate of hospitalization and the incidence of iron overload-related comorbidities in patients with hemochromatosis between the years of 2002 and 2010.We queried the Nationwide Inpatient Sample(NIS)database from the year 2002 to 2010.We included adults(age≥18 years)and used the ICD-CM 9 code 275.0x to identify hospitalized patients with a diagnosis of hemochromatosis.Data analysis for this study was generated using SAS software version 9.4.A total of 168,614 hospitalized patients between 2002 and 2010 had a diagnosis of hemochromatosis.The majority were males(57%)with a median age of 54 years(37–68),with a predominance of white patients(63.3%)followed by black(26.8%).The rate of hospitalization among patients with hemochromatosis increased by 79%between the years 2002 and 2010(34.5/100,000 in 2002 vs 61.4/100,000 in 2010).The main associated diagnoses were diabetes mellitus(20.2%),cardiac disease,including arrhythmias(14%)and cardiomyopathy(dilated 3.8%;peri-,endo-,myocarditis 1.3%),liver cirrhosis(8.6%),HCC(1.6%),and acute liver failure(0.81%).Of note,HCC was associated with cirrhosis in 1188 patients(43%of HCC patients)and male sex(87%).Diagnostic biopsies were performed in 6023(3.6%)of those patients and liver transplant was performed in 881(0.5%).In-hospital mortality occurred in 3638(2.16%)patients.In this large database study,we found a rising trend in hospitalization for hemochromatosis,possibly due to the increased recognition of this entity and billing for the condition.The incidence of cirrhosis in hemochromatosis was found to be similar to other studies(8.6%vs 9%).However,the

关 键 词：Diabetes mellitus HEMOCHROMATOSIS Hepatocellular carcinoma HOSPITALIZATION Iron overload Liver cirrhosis 

分 类 号：R552[医药卫生—血液循环系统疾病]