沙格列汀联合二甲双胍治疗对改善绝经后2型糖尿病患者代谢影响的研究  

Effects of Saxagliptin combined with Metformin on metabolism in postmenopausal type 2 diabetes mellitus patients

作　　者：陈璐 张楠[1] 安洁 CHEN Lu;ZHANG Nan;AN Jie(Department of Endocrinology,Run Run Shaw Hospital Afiliated to Zhejiang University School of Medicine,Hangzhou 310003,China)

机构地区：[1]浙江大学医学院附属邵逸夫医院内分泌科 [2]华北理工大学附属开滦总医院质控办

出　　处：《中国糖尿病杂志》2023年第4期270-273,共4页Chinese Journal of Diabetes

基　　金：国家自然科学基金(30700300);浙江省卫生厅项目(2007A120)。

摘　　要：目的探讨沙格列汀联合二甲双胍治疗对改善绝经后T2DM患者代谢的影响。方法选取2018年6月至2019年1月于华北理工大学附属开滦总医院内分泌科治疗的绝经后T2DM患者120例,随机分为二甲双胍组(Met)和二甲双胍联合沙格列汀组(Met+Sag),每组各60例。比较两组治疗前后骨钙素(OC)、骨碱性磷酸酶(BALP)、Ⅰ型前胶原氨基末端前肽(PINP)、Ⅰ型胶原蛋白C末端交联肽(CTX-β)、尿液中吡啶啉(PYD)、骨密度(BMD)、全身脂肪百分比(FAT%)、腹/臀部脂肪比(A/G)、内脏脂肪面积(VFA)、脂肪量指数(FMI)、FPG、HbA1c、TC、TG等。结果治疗后Met+Sag组BALP、BMD、PINP、CTX-β、PYD、HDL-C、HOMA-β及VFA高于Met组(P<0.05),OC、FPG、HbA1c、LDL-C、HOMA-IR、FAT%、A/G、FMI、TC及TG低于Met组(P<0.05)。结论二甲双胍联合沙格列汀治疗绝经后T2DM患者,可有效改善糖脂、BMD及骨转换标志物水平,VFA、FMI治疗效果更佳。Objective To investigate the effect of Saxagliptin combined with Metformin on metabolism in postmenopausal patients with type 2 diabetes mellitus(T2DM).Methods A total of 120 postmenopausal T2DM patients admitted to the Department of Endocrinology,Kailuan-based General Hospital Affiliated to North China University of Science and Technology from June 2018 to January 2019 were randomly divided into Metformin group(Met)and Metformin plus Saxagliptin group(Met+Sag),with 60 cases in each group.Osteocalcin(OC),bone alkaline phosphatase(BALP),amino terminal propeptide of type I procollagen(PINP),C-terminal cross-linked peptide of type I collagen(CTX-β),urine pyridine(PYD),bone mineral density(BMD),total body FAT percentage(FAT%),abdominal/hip fat ratio(A/G),visceral fat area(VFA),fat mass index(FMI),FPG,HbAic,TC,TG,etc.Results After treatment,the levels of BALP,BMD,PINP,CTX-β,PYD,HDL-C,HOMA-βand VFA in Met+Sag group were higher than those in Met group(P<0.05),OC,FPG,HbAic,LDL-C,HOMA-IR,FAT%,A/G,FMI,TC and TG were lower than those in Met group(P<0.05).Conclusion Metformin combined with Saxagliptin can effectively improve glycolipid and bone metabolism of postmenopausal T2DM patients,especially in VFA and FMI indicators.

关 键 词：骨代谢 沙格列汀 二甲双胍 糖尿病 2型 

分 类 号：R587.1[医药卫生—内分泌]