肠道菌群及其代谢产物早期诊断糖尿病肾脏疾病的研究进展  

Research progress of intestinal flora and various metabolites in early diagnosis of diabetic kidney disease

作　　者：叶锦玲 罗群[2] 蔡珂丹[2] YE Jinling;LUO Qun;CAI Kedan(Ningbo University School of Medicine,Ningbo 315211,China)

机构地区：[1]宁波大学医学院,315211 [2]宁波市第二医院肾内科

出　　处：《中国糖尿病杂志》2023年第4期309-312,共4页Chinese Journal of Diabetes

基　　金：浙江省自然科学基金(LY20H050005);浙江省医药卫生科技项目(2019KY174);宁波市公益基金(2019C50084);省市共建医学重点学科(2022-S03)。

摘　　要：DM是全球第三大非感染性疾病,DKD是慢性肾脏病的主要原因。良好的生物标志物为临床早期识别并干预DKD发挥作用。尿微量白蛋白、血肌酐、外泌体、炎症标志物等生物标志物已广泛用于DKD诊治,但敏感性和特异性不足。本文综述肠道菌群及其代谢产物早期诊断DKD的研究进展。Diabetes mellitus(DM)is the third largest noncommunicable diseases in the world.Diabetic kidney disease(DKD)is the main cause of chronic kidney disease.Good biomarkers play an important role in early clinical identification and early intervention of DKD.Urinary microalbumin,blood creatinine,secretion,inflammatory factors and other biomarkers are widely used in the diagnosis and treatment of DKD,but their sensitivity and specificity are insufficient.This article reviews the research progress of intestinal flora and various metabolites in the early diagnosis of DKD.

关 键 词：肠道菌群 糖尿病肾脏疾病 生物标志物 靶点 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]