妊娠母体免疫激活动物模型研究进展  

Research advances in animal models of maternal immune activation during pregnancy

作　　者：邬建飞 蔡端芳 谭友果[1,2] 蒲建林 向波 王丙龙 WU Jianfei;CAI Duanfang;TAN Youguo;PU Jianlin;XIANG Bo;WANG Binglong(Zigong Psychiatric Research Center,Zigong 643020,China;Zigong Institute of Brain Science,Zigong 643020;Departmen of Psychiatry,Affiliated Hospital of Southwest Medical University,Luzhou 646000)

机构地区：[1]自贡市精神卫生中心,四川自贡643020 [2]自贡市脑科学研究院,四川自贡643020 [3]西南医科大学附属医院精神科,四川泸州646000

出　　处：《中国实验动物学报》2023年第4期507-513,共7页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金(82001414);自贡市重点科技计划项目(2022ZCNKY21)。

摘　　要：妊娠期间对母体免疫系统的刺激会导致母体免疫激活(maternal immune activation,MIA),流行病学研究显示MIA会增加子代神经发育障碍的风险,进而诱导子代罹患自闭症谱系障碍(autism spectrum disorder,ASD)、精神分裂症(schizophrenia,SZ)和神经管缺陷(neural tube defects,NTD)等精神疾病,MIA动物模型的建立对深入研究相关精神疾病的发病机制和探索有效的预防治疗方案至关重要。本文将对MIA实验动物的选择、建模药物的选择、子代的病理变化及相关治疗方案进行综述,以期为相关实验研究和临床治疗提供一定的理论参考。Maternal immune activation(MIA)result from immune system stimulation during pregnancy.In addition,it can cause the offspring to develop autism spectrum disorder(ASD),schizophrenia(SZ),neural tube defects(NTD),and other mental illness,according to epidemiological research,which have indicated that MIA increases the chance of neurodevelopmental abnormalities in kids.To better understand the pathophysiology of linked mental illnesses and investigate efficient preventative and treatment options,it is crucial to construct animal models of MIA.In order to provide theoretical guidance for the pertinent experimental research and clinical therapy,this paper analyzes the selection of animals used to test MIA,the choice of modeling medications,the pathological alterations of offspring,and the applicable therapeutic options.

关 键 词：MIA动物模型 神经发育障碍 精神疾病 

分 类 号：Q95-33[生物学—动物学]