酒精使用障碍动物模型构建的研究进展  

Advances in establishment of alcohol use disorder models

作　　者：吕振 龚志刚[1,2] LYU Zhen;GONG Zhigang(Key Lab of Aquatic Sports Training Monitoring and 1ntervention of General Administration of Sport of China,Jiangxi Normal University,Nanchang 330022,China;Faculty of Physical Education,Jiangxi Normal University,Nanchan 330022)

机构地区：[1]江西师范大学国家体育总局水上项目训练监控与干预重点实验室,南昌330022 [2]江西师范大学体育学院,南昌330022

出　　处：《中国实验动物学报》2023年第3期382-389,共8页Acta Laboratorium Animalis Scientia Sinica

基　　金：江西省教育厅研究生创新基金(YC2021-S276);江西省教育厅科学技术研究项目(GJ2200337)。

摘　　要：酒精使用障碍(alcohol use disorder,AUD)是一种与行为学、社会心理学和神经生物学等方面相关的神经精神疾病,也定义为酗酒和酒精依赖。由于AUD的诊断主要依赖于行为标准的判断,诊断具有复杂性,难以建立包含所有AUD特征的动物模型。本文对国内外相关文献总结归纳,将AUD模型分为强迫给药模型和自身给药模型,比较了两种模型所包含的酒精唯一饮用方法、酒精灌胃方法、酒精流食方法、慢性间歇性酒精蒸气暴露方法、两瓶选择方法、操作性自身给药方法的优缺点,从表观效度、预测效度和结构效度三方面对造模方法进行探究,以期为AUD研究者在动物造模方法的选择上提供有益参考。Alcohol use disorder(AUD)is a neuropsychiatric disorder associated with behavior,psychosociology,and neurobiology.AUD is mainly diagnosed by judgment of behavioral criteria.The animal model of AUD is the basis of research.However,because of the complexity of AUD diagnosis,it is too difficult to establish an animal model that includes all characteristics of AUD.This review summarizes the relevant literature and divides the AUD model into forced administration and self-administration models.The advantages and disadvantages of alcohol-only drinking,alcohol gavage,an alcohol liquid diet,chronic intermittent ethanol exposure,two-bottle choice,and alcohol self-administration included in both models are described and compared.Additionally,the modeling method were explored by face,predictive,and construct validities to provide a theoretical basis and reference for researchers to choose AUD models.

关 键 词：酒精使用障碍 动物模型 酒精使用障碍模型 酒精 

分 类 号：Q95-33[生物学—动物学]