移植性肺癌动物模型研究进展  

Research progress of transplanted lung cancer animal model

作　　者：薛艳芳 王莉翠 周依舒 黄劲柏 XUE Yanfang;WANG Licui;ZHOU Yishu;HUANG Jinbai(Health Science Center,Yangtze University,Jingzhou 434023,China;PET Center,the First Affiliated Hospital of Yangtze University,Jingzhou 434021)

机构地区：[1]长江大学医学部,湖北荆州434023 [2]长江大学附属第一医院PET中心,湖北荆州434021

出　　处：《中国实验动物学报》2023年第3期410-416,共7页Acta Laboratorium Animalis Scientia Sinica

摘　　要：肺癌发病率和死亡率高,建立合适的肺癌动物模型对其发病原因、机制、药物作用等进行还原性研究非常重要。其中,移植性肺癌动物模型因移植方法多样且操作简便而被广泛应用。本文从移植宿主、移植物来源及造模方法三方面对移植性肺癌动物模型中的原位移植及异位移植进行综述,为肺癌模型的构建和选择提供思路。The incidence and mortality of lung cancer are high.It is very important to establish an appropriate animal model of lung cancer to conduct reductive studies on its pathogenesis,mechanism,and drug effects.Animal models of transplanted lung cancer are widely used because of the various transplantation method and simple operation.This article reviews orthotopic and heterotopic transplantation in animal models of transplanted lung cancer from three aspects,the transplantation host,source of the graft,and method of establishment,to provide ideas to establish and select lung cancer models.

关 键 词：肺癌 动物模型 原位移植 异位移植 

分 类 号：Q95-33[生物学—动物学]