Craniofacial therapy:advanced local therapies from nano-engineered titanium implants to treat craniofacial conditions  

作　　者：Karan Gulati Chengye Ding Tianqi Guo Houzuo Guo Huajie Yu Yan Liu 

机构地区：[1]The University of Queensland,School of Dentistry,Herston,QLD,Australia [2]Laboratory of Biomimetic Nanomaterials,Department of Orthodontics,Peking University School and Hospital of Stomatology,Beijing,China [3]National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental Materials,Beijing,China [4]Department of Oral Implantology,Peking University School and Hospital of Stomatology,Beijing,China [5]Fourth Clinical Division,Peking University School and Hospital of Stomatology,Beijing,China

出　　处：《International Journal of Oral Science》2023年第1期33-49,共17页国际口腔科学杂志（英文版）

基　　金：supported by the National Natural Science Foundations of China 82230030 and 81871492(Y.L.);Beijing International Science and Technology Cooperation Project No.Z221100002722003(Y.L.);Ten-Thousand Talents Program QNBJ2019–2(Y.L.);Key R&D Plan of Ningxia Hui Autonomous Region 2020BCG01001(Y.L.);Innovative Research Team of High-level Local Universities in Shanghai SHSMUZLCX20212402(Y.L.);the National Health and Medical Research Council Early Career Fellowship APP1140699(K.G.)。

摘　　要：Nano-engineering-based tissue regeneration and local therapeutic delivery strategies show significant potential to reduce the health and economic burden associated with craniofacial defects,including traumas and tumours.Critical to the success of such nano-engineered non-resorbable craniofacial implants include load-bearing functioning and survival in complex local trauma conditions.Further,race to invade between multiple cells and pathogens is an important criterion that dictates the fate of the implant.In this pioneering review,we compare the therapeutic efficacy of nano-engineered titanium-based craniofacial implants towards maximised local therapy addressing bone formation/resorption,soft-tissue integration,bacterial infection and cancers/tumours.We present the various strategies to engineer titanium-based craniofacial implants in the macro-,micro-and nano-scales,using topographical,chemical,electrochemical,biological and therapeutic modifications.A particular focus is electrochemically anodised titanium implants with controlled nanotopographies that enable tailored and enhanced bioactivity and local therapeutic release.Next,we review the clinical translation challenges associated with such implants.This review will inform the readers of the latest developments and challenges related to therapeutic nano-engineered craniofacial implants.

关 键 词：IMPLANTS TITANIUM LOCAL 

分 类 号：R318.08[医药卫生—生物医学工程] TB383.1[医药卫生—基础医学] TG146.23[一般工业技术—材料科学与工程]