Detection,regulation,and functions of RNA N^(6)-methyladenosine modification in plants  

作　　者：Jun Tang Shuyan Chen Guifang Jia 

机构地区：[1]Synthetic and Functional Biomolecules Center,Beijing National Laboratory for Molecular Sciences,Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China [2]Peking-Tsinghua Center for Life Sciences,Beijing 100871,China

出　　处：《Plant Communications》2023年第3期32-46,共15页植物通讯（英文）

基　　金：supported by the National Natural Science Foundation of China(22225704,21820102008,92053109);the National Basic Research Program of China(2019YFA0802201);the Beijing Natural Science Foundation(Z200010).

摘　　要：N6-Methyladenosine(m^(6)A)is the most abundant internal chemical modification in eukaryotic mRNA and plays important roles in gene expression regulation,including transcriptional and post-transcriptional regulation.m^(6)A is a reversible modification that is installed,removed,and recognized by methyltransferases(writers),demethylases(erasers),and m^(6)A-binding proteins(readers),respectively.Recently,the breadth of research on m^(6)A in plants has expanded,and the vital roles of m^(6)A in plant development,biotic and abiotic stress responses,and crop trait improvement have been investigated.In this review,we discuss recent developments in research on m^(6)A and highlight the detection methods,distribution,regulatory proteins,and molecular and biological functions of m^(6)A in plants.We also offer some perspectives on future investigations,providing direction for subsequent research on m^(6)A in plants.

关 键 词：RNA modification m^(6)A PLANTS epitranscriptome 

分 类 号：Q943[生物学—植物学]