Parallel evolution of twoAIM24 protein subfamilies and their conserved functions in ER stress tolerance in land plants  

作　　者：Yanlong Guan Guanxiao Chang Jinjie Zhao Qia Wang Jiali Qin Mengmeng Tang Shuanghua Wang Lan Ma Jianchao Ma Guiling Sun Yun Zhou Jinling Huang 

机构地区：[1]Key Laboratory for Plant Diversity and Biogeography of East Asia,Yunnan Key Laboratory for Fungal Diversity and Green Development,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China [2]State Key Laboratory of Crop Stress Adaptation and Improvement,School of Life Sciences,Henan University,Kaifeng 475004,China [3]Yunnan Key Laboratory for Wild Plant Resources,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China [4]Department of Biology,East Carolina University,Greenville,NC 27858,USA

出　　处：《Plant Communications》2023年第3期183-196,共14页植物通讯（英文）

基　　金：supported in part by grants from the National Natural Science Foundation of China(31970248,32070251,32170242);Yunnan Fundamental Research Projects(202101AT070186,202201AT070163);Postdoctoral Research Funding Projects of Yunnan Province,the Special Research Assistant Funding Project of the Chinese Academy of Sciences(2021);the China Postdoctoral Science Foundation(2022M723223);the Youth Innovation Promotion Association CAS(2022398).

摘　　要：Despite decades of efforts in genome sequencing and functional characterization,some important protein families remain poorly understood.In this study,we report the classification,evolution,and functions of the largely uncharacterized AIM24 protein family in plants,including the identification of a novel subfamily.We show that two AIM24 subfamilies(AIM24-A and AIM24-B)are commonly distributed in major plant groups.These two subfamilies not only have modest sequence similarities and different gene structures but also are of independent bacterial ancestry.We performed comparative functional investigations on the two AIM24 subfamilies using three model plants:the moss Physcomitrium patens,the liverwort Marchantia polymorpha,and the flowering plant Arabidopsis thaliana.Intriguingly,despite their significant differences in sequence and gene structure,both AIM24 subfamilies are involved in ER stress tolerance and the unfolded protein response(UPR).In addition,transformation of the AIM24-A gene from P.patens into the AIM24-B null mutant of A.thaliana could at least partially rescue ER stress tolerance and the UPR.We also discuss the role of AIM24 genes in plant development and other cellular activities.This study provides a unique example of parallel evolution in molecular functions and can serve as a foundation for further investigation of the AIM24 family in plants.

关 键 词：Physcomitrium MARCHANTIA unfolded protein response lncRNA 

分 类 号：Q94[生物学—植物学]