Two-component system GacS/GacA,a global response regulator of bacterial physiological behaviors  

作　　者：Huihui Song Yuying Li Yan Wang 

机构地区：[1]College of Marine Life Sciences,Ocean University of China,Qingdao 266003,China [2]Laboratory for Marine Ecology and Environmental Science,Qingdao National Laboratory for Marine Science and Technology,Qingdao 266071,China [3]Institute of Evolution and Marine Biodiversity,Ocean University of China,Qingdao 266003,China

出　　处：《Engineering Microbiology》2023年第1期37-48,共12页工程微生物学（英文）

基　　金：supported by the National Natural Science Foundation of China(42176108,31870023);the Young Taishan Scholars Program of Shandong Province(tsqn202103029);the Fundamental Research Funds for the Central Universities(201941009).

摘　　要：The signal transduction system of microorganisms helps them adapt to changes in their complex living environment.Two-component system(TCS)is a representative signal transduction system that plays a crucial role in regulating cellular communication and secondary metabolism.In Gram-negative bacteria,an unorthodox TCS consist-ing of histidine kinase protein GacS(initially called LemA)and response regulatory protein GacA is widespread.It mainly regulates various physiological activities and behaviors of bacteria,such as quorum sensing,secondary metabolism,biofilm formation and motility,through the Gac/Rsm(Regulator of secondary metabolism)signaling cascade pathway.The global regulatory ability of GacS/GacA in cell physiological activities makes it a potential research entry point for developing natural products and addressing antibiotic resistance.In this review,we summarize the progress of research on GacS/GacA from various perspectives,including the reaction mechanism,related regulatory pathways,main functions and GacS/GacA-mediated applications.Hopefully,this review will facilitate further research on GacS/GacA and promote its application in regulating secondary metabolism and as a therapeutic target.

关 键 词：GacS/GacA Two-component system Signaling regulatory network Secondary metabolite Antibiotic resistance 

分 类 号：Q93[生物学—微生物学]