Ten decadal advances in fungal biology leading towards human well‑being  

作　　者：Ausana Mapook·Kevin DHyde Kevin D.Hyde Khadija Hassan Blondelle Matio Kemkuignou Adela Cmokova Frank Surup Eric Kuhnert Pathompong Paomephan Tian Cheng Sybren de Hoog Yinggai Song Ruvishika S.Jayawardena Abdullah M.S.Al‑Hatmi Tokameh Mahmoudi Nadia Ponts Lena Studt‑Reinhold Florence Richard‑Forget K.W.Thilini Chethana Dulanjalee L.Harishchandra Peter E.Mortimer Huili Li Saisamorm Lumyong Worawoot Aiduang Jaturong Kumla Nakarin Suwannarach Chitrabhanu S.Bhunjun Feng‑Ming Yu Qi Zhao Doug Schaefer Marc Stadler 

机构地区：[1]Center of Excellence in Fungal Research,Mae Fah Luang University,Chiang Rai 57100,Thailand [2]School of Science,Mae Fah Luang University,Chiang Rai 57100,Thailand [3]Department Microbial Drugs,Helmholtz Centre for Infection Research(HZI),and German Centre for Infection Research(DZIF),Partner Site Hannover‑Braunschweig,Inhoffenstrasse 7,38124 Brunswick,Germany [4]Institute of Microbiology,Technische Universitat Braunschweig,Spielmannstrase 7,38106 Brunswick,Germany [5]Laboratory of Fungal Genetics and Metabolism,Institute of Microbiology,Czech Academy of Sciences,Prague,Czech Republic [6]Centre of Biomolecular Drug Research(BMWZ),Institute for Organic Chemistry,Leibniz University Hannover,Schneiderberg 38,30167 Hannover,Germany [7]Department of Biotechnology,Faculty of Science,Mahidol University,272 Rama VI Road,Ratchathewi,Bangkok 10400,Thailand [8]Center of Expertise in Mycology,Radboud University Medical Center/Canisius Wilhelmina Hospital,Nijmegen,The Netherlands [9]Key Laboratory of Environmental Pollution Monitoring and Disease Control,Guizhou Medical University,Guiyang,China [10]Microbiology,Parasitology and Pathology Graduate Program,Federal University of Parana,Curitiba,Brazil [11]Department of Dermatology,Peking University First Hospital,Peking University,Beijing,China [12]Natural and Medical Sciences Research Center,University of Nizwa,Nizwa,Oman [13]Department of Biochemistry,Erasmus University Medical Center,Rotterdam,The Netherlands [14]INRAE,UR1264 Mycology and Food Safety(MycSA),33882 Villenave d’Ornon,France [15]Department of Applied Genetics and Cell Biology,Institute of Microbial Genetics,University of Natural Resources and Life Sciences,Vienna(BOKU),Tulln an der Donau,Austria [16]Beijing Key Laboratory of Environment Friendly Management on Fruit Diseases and Pests in North China,Institute of Plant Protection,Beijing Academy of Agriculture and Forestry Sciences,Beijing 100097,China [17]Key Laboratory for Plant Diversity and Biogeography of East Asia,Kunming Institute of Botany,Chinese Aca

出　　处：《Fungal Diversity》2022年第5期547-614,共68页真菌多样性（英文）

基　　金：Funding Open Access funding enabled and organized by Projekt DEAL.Funding was provided by Mae Fah Luang University(Grant No.:651A16029);Basic Research Fund(Grant No.:652A01001);Princess Srinagarindra’s Centenary Celebrations Foundation(Grant No.:64316001);National Research Council Thailand(Grant No.:NRCT5-TRG630010-01);Czech Academy of Sciences Long-term Research Development Project(Grant No.:61388971);Thailand Research Fund(Grant No.:PHD/0039/2560);Deutscher Akademischer Austauschdienst(Grant Nos.:57507870,PhD stipend),Czech Academy of Sciences(Grant No.:CZ.02.2.69/0.0/0.0/18_053/0017705);Chiang Mai University(Grant No.:FF65/067);STEP Program(CH)(Grant No.:2019QZKK0503);Kunming Institute of Botany,Chinese Academy of Sciences(Grant No.:292019312511043).

摘　　要：Fungi are an understudied resource possessing huge potential for developing products that can greatly improve human well-being.In the current paper,we highlight some important discoveries and developments in applied mycology and interdisciplinary Life Science research.These examples concern recently introduced drugs for the treatment of infections and neurological diseases;application of–OMICS techniques and genetic tools in medical mycology and the regulation of mycotoxin production;as well as some highlights of mushroom cultivaton in Asia.Examples for new diagnostic tools in medical mycology and the exploitation of new candidates for therapeutic drugs,are also given.In addition,two entries illustrating the latest developments in the use of fungi for biodegradation and fungal biomaterial production are provided.Some other areas where there have been and/or will be significant developments are also included.It is our hope that this paper will help realise the importance of fungi as a potential industrial resource and see the next two decades bring forward many new fungal and fungus-derived products.

关 键 词：Biomaterial CRISPR Drug development Morel cultivation Mushroom cultivation Mycotoxin biosynthesis Plastic degradation 

分 类 号：Q949.3[生物学—植物学]