复合纳米材料制备及其光热性能的综合实验设计  

Synthesis and Experimental Design of Photothermal Properties of Composite Nanomaterials

作　　者：贾承政 胡云霞 郭嘉萱 王世革[1] JIA Chengzheng;HU Yunxia;GUO Jiaxuan;WANG Shige(School of Materials and Chemistry,University of Shanghai for Science and Technology,Shanghai 200093,China)

机构地区：[1]上海理工大学材料与化学学院,上海200093

出　　处：《实验室研究与探索》2023年第2期31-35,60,共6页Research and Exploration In Laboratory

基　　金：国家自然科学基金项目(81972904);上海市大学生创新创业训练计划项目(XJ2022513);上海理工大学材料与化学学院“十四五”重点攻关课题(SSWGGKT004)。

摘　　要：设计了基于水热法制备高分散纳米粒子Fe_(3)O_(4),并在其外层包覆具有介孔结构的二氧化硅(MSN)和光热转换能力的聚吡咯(PPy),并将井血清蛋白(BSA)修饰到纳米粒子外层,形成具有良好生物相容性的复合材料。利用扫描电镜、透射电镜、EDS、X射线衍射等仪器对材料进行结构和组成的表征。模拟在肿瘤微环境下生成具有细胞毒性的羟基自由基并评价其催化活性,测试了其光热转换的性能。实验结果表明,在近红外光照射下,复合纳米粒子的光热转换效率为24.13%,具有良好的光热转换能力。复合材料展现出的顺磁性和介孔结构,为其在肿瘤治疗应用中具有良好磁靶向性和高载药能力提供了前提,特别是其外层包覆PPy后具有的光热转换能力为近红外激光消融肿瘤提供了良好的治疗平台,同时结合其自身的催化能力进一步拓展了材料应用化学动力学疗法杀死肿瘤细胞的新思路。Composite nanoparticles show multiple therapeutic methods,which effectively expand their application prospects in tumor therapy.The preparation and performance experiments of composite nanoparticles are introduced into the experimental teaching of applied chemistry.A highly dispersed nano particle Fe_(3)O_(4) is designed based on hydrothermal method,and its outer layer is coated with mesoporous silica and polypyrrole(PPy)which has hotothermal conversion ability.The structure,composition and structure of the material are characterized by scanning electron microscope,transmission electron microscope,EDS and X-ray diffraction.We simulate the generation of cytotoxic hydroxyl radicals in the tumor microenvironment,evaluate their catalytic activity,and test their photothermal conversion performance.The experimental results show that under near-infrared light irradiation,the photothermal conversion efficiency of the composite nanoparticles is 24.13%,which has good photothermal conversion ability.The paramagnetism and mesoporous structure of the composite material provide the premise for its good magnetic targeting and high drug loading ability in tumor treatment applications,especially the photothermal conversion ability of its outer coating of PPy,which provides a good treatment platform for near-infrared laser ablation of tumors.At the same time,combined with its own catalytic ability,it further expands the new idea of material application of chemokinetic therapy to kill tumor cells.

关 键 词：复合纳米粒子 磁性材料 光热 

分 类 号：TB33[一般工业技术—材料科学与工程]