不同作用机制临床在研抗抑郁药物研究进展  

Progress in the clinical study of antidepressant drugs with different mechanisms

作　　者：王慧莹 周爱南 吴建威 解鹏[3] 李建其[3] WANG Hui-ying;ZHOU Ai-nan;WU Jian-wei;XIE Peng;LI Jian-qi(School of Chemistry and Chemical Engineering,Shanghai University of Engineering Science,Shanghai 201620,China;Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;New Technology Center of Chemical Pharmacy,Shanghai Institute of Pharmaceutical Industry,China General Research Institute of Pharmaceutical Industry,Shanghai 201203,China)

机构地区：[1]上海工程技术大学化学化工学院,上海201620 [2]中国科学院上海药物研究所,上海201203 [3]中国医药工业研究总院上海医药工业研究院化学制药新技术中心,上海201203

出　　处：《中国新药杂志》2023年第7期676-686,共11页Chinese Journal of New Drugs

摘　　要：目前上市的治疗抑郁症(major depressive disorder,MDD)药物存在一定的局限性,其不同的作用机制与药效及安全性密切相关,因此发现新作用机制的抗抑郁药为目前MDD治疗领域的重要研究方向。本文综述了目前处于临床研究阶段的部分主要抗抑郁药物,分析其作用机制,为研发新作用机制的抗抑郁药物提供参考。At present,the listed antidepressants have certain limitations,and the different mechanisms of which are closely related to their efficacy and safety.Therefore,the discovery of antidepressants with novel mechanisms is an important research direction in the field of antidepressants.This paper reviews some major antidepressants currently under clinical research stage,and analyzes their mechanisms of action,so as to provide reference for the development of antidepressants with new mechanisms of action.

关 键 词：抑郁症药物 局限性 作用机制 临床研究 

分 类 号：R971.4[医药卫生—药品]