《世界卫生组织儿童基本药物目录》与《国家基本药物目录》中消化系统用药的分析与启示  

Analysis and Enlightenment of Digestive System Medicines in World Health Organization Model List of Essential Medicines for Children and National Essential Medicines List

作　　者：高石曼 刘畅[1] 闫美兴 Gao Shiman;Liu Chang;Yan Meixing(Women and Children’s Hospital,Qingdao University,Qingdao Women and Children’s Hospital,Shandong Qingdao 266034,China)

机构地区：[1]青岛大学附属妇女儿童医院,青岛市妇女儿童医院,山东青岛266034

出　　处：《儿科药学杂志》2023年第5期1-6,共6页Journal of Pediatric Pharmacy

摘　　要：目的:为遴选国家儿童基本药物目录中消化系统用药提供参考。方法:描述性分析第7版《世界卫生组织(WHO)儿童基本药物目录》(WHO-EMLc)与2018版《国家基本药物目录》(NEML)中消化系统用药在分类与数量、剂型规格、标志符号等方面的异同,比较两目录收录的消化系统用药在我国的上市情况,调查NEML收录的消化系统用药在国内药品说明书中关于儿童用药的规定。结果:WHO-EMLc和NEML中通用名相同的消化系统用药为奥美拉唑、雷尼替丁及甲氧氯普胺。与NEML相比,WHO-EMLc中消化系统用药的剂型和规格更为具体,且包含药物疗效、安全性、年龄限制及注意事项的符号标记。两目录收录的消化系统用药在我国的上市剂型以普通剂型为主,儿童适宜剂型相对较少。NEML收录的消化系统用药中,55.17%的品种在国内药品说明书中规定了儿童适应证的用法用量。结论:以《WHO儿童基本药物目录》和《国家基本药物目录》为基础,遴选我国儿童消化系统基本药物,进一步鼓励儿童消化系统专用药物的研发,保障儿童用药的安全性、有效性、可及性和顺应性。Objective:To provide references for the selection of digestive system medicines in National List of Essential Medicines for children.Methods:A descriptive analysis was conducted to compare the similarities and differences between the 7th edition of World Health Organization Model List of Essential Medicines for Children(WHO-EMLc)and the 2018 edition of National Essential Medicines List(NEML)in terms of classification,quantity,dosage form,specification,symbol,etc.Besides,the marketing situation of digestive system medicines included in WHO-EMLc and NEML in China was compared,and the regulations on children’s usage in domestic medicine specifications of digestive system medicines included in NEML were investigated.Results:In WHO-EMLc and NEML,digestive system medicines with the same generic name were Omeprazole,Ranitidine and Metoclopramide.Compared with NEML,the dosage form and specification of digestive system medicines in WHO-EMLc were more specific,and symbols of efficacy and safety,age restrictions and precautions were marked in WHO-EMLc.The marketed dosage forms of digestive system medicines in the two lists were mainly ordinary dosage forms in China,and relatively few dosage forms were suitable for children.And 55.17%of digestive system medicines included in NEML prescribed the usage and dosage for children in domestic medicine specifications.Conclusion:The selection of digestive system essential medicines for children in our country could be carried out on the basis of WHO-EMLc and NEML,and scientific research and development of special digestive system medicines for children should be further encouraged,so as to ensure the safety,effectiveness,accessibility and compliance of medication for children.

关 键 词：世界卫生组织儿童基本药物目录 国家基本药物目录 消化系统用药 

分 类 号：R969.3[医药卫生—药理学]