关于“隐匿性HBV感染”定义的拙见  

Opinion on the definition of“occult hepatitis B virus infection”

作　　者：薛荣荣 王欣茹 肖丽[2] 刘成元 王蔚[2] 徐洪涛[2] 咸建春[2] XUE Rongrong;WANG Xinru;XIAO Li;LIU Chengyuan;WANG Wei;XU Hongtao;XIAN Jianchun(Department of Infectious Diseases,the First People’s Hospital of Yancheng,Yancheng,Jiangsu 224005,China;Department of Infectious Diseases and Hepatology,Taizhou People’s Hospital,Taizhou,Jiangsu 225300,China)

机构地区：[1]江苏省盐城市第一人民医院感染性疾病科,江苏盐城224005 [2]江苏省泰州市人民医院感染暨肝病科,江苏泰州225300

出　　处：《临床肝胆病杂志》2023年第5期1037-1040,共4页Journal of Clinical Hepatology

基　　金：泰州市科技支撑计划(社会发展)项目(TS201813)。

摘　　要：隐匿性HBV感染(OBI)诊断的充分必要条件是指HBsAg阴性个体的肝脏和/或血清中存在具有复制能力的HBV DNA。我国学者近年来对其提出认为是更“严谨”的定义:即在此基础上,排除HBV窗口期(WP)感染,对应血清HBV DNA低于检测下限或低值阳性(<200 IU/mL)。因HBV感染WP的定义尚不明确、持续时间的高度可变性,而“HBV DNA<200 IU/mL”不是OBI患者的全部。故认为以“排除HBV感染WP”与“HBV DNA<200 IU/mL”为诊断OBI“严谨”条件的OBI定义还缺乏充分的依据与可操作性。The presence of replication-competent HBV DNA in the liver and/or serum of HBsAg-negative individuals is a sufficient and necessary condition for the diagnosis of occult hepatitis B virus infection(OBI).In recent years,Chinese scholars have proposed what is considered a more“rigorous”definition,i.e.,on this basis,HBV window period(WP)infection is excluded,which corresponds to a serum HBV DNA level of below the lower limit of detection or a low positive value(<200 IU/mL).[JP3]As the definition of WP for HBV infection remains unclear and its duration is highly variable,“HBV DNA<200 IU/mL”is not the only criterion in OBI patients.Therefore,it is believed that there is still a lack of sufficient basis and operability for the definition of OBI based on“the exclusion of HBV WP infection”and“HBV DNA<200 IU/mL”as“rigorous”conditions for the diagnosis of OBI.

关 键 词：乙型肝炎病毒 乙型肝炎 病毒载量 

分 类 号：R512.62[医药卫生—内科学]