菏泽市水源性高碘地区50岁以上人群甲状腺疾病的流行病学调查研究  

Epidemiological investigation study of thyroid disease in people over 50 years old in water-borne high iodine areas in Heze City

作　　者：陈素雨 王一川 李美玲 宋玉娟[1] CHEN Suyu;WANG Yichuan;LI Meiling;SONG Yujuan(Heze Medical College,Heze,Shandong 274000,China)

机构地区：[1]菏泽医学专科学校,山东274000

出　　处：《中国地方病防治》2023年第2期91-94,104,共5页Chinese Journal of Control of Endemic Diseases

基　　金：山东省医药卫生科技发展计划项目(202004011370)。

摘　　要：目的 调查菏泽市水源性高碘地区50岁以上常住居民的甲状腺疾病发病情况及存在的危险因素,为正确指导甲状腺疾病预防、制定防治策略提供依据。方法 随机抽取菏泽市牡丹区50岁及以上常住居民9 900人,男、女各4 450人,50~59岁,60~69岁,70岁及以上年龄分层各3 300人,进行问卷调查、检测尿碘,采血测定血清T_(3)、T_(4)及促甲状腺激素(TSH),进行甲状腺检查。结果 60~69岁年龄人群血清T_(3)、T_(4)、TSH结果高于50~59岁、70岁及以上人群,女性血清T_(3)、T_(4)、TSH结果高于男性,差异有统计学意义(P<0.05)。50~59岁、60~69岁、70岁及以上人群尿碘分别为(324.92±98.49)、(337.08±101.32)、(343.35±104.08)μg/L,差异无统计学意义(P>0.05)。60~69岁年龄和女性人群血清T_(3)、T_(4)、TSH异常总发生率为5.61%和6.54%,结果高于50~59岁人群(3.30%)、70岁及以上人群(4.52%)和男性人群(1.82%),差异有统计学意义(P<0.05);60~69岁年龄和女性人群甲状腺疾病总患病率为3.15%和3.64%,结果高于50~59岁人群(2.39%)和男性人群(2.67%),差异有统计学意义(P<0.05);60~69岁年龄和女性人群甲状腺肿大总发生率为2.15%和2.27%,高于50~59岁人群(1.12%)、70岁及以上人群(1.42%)和男性人群(1.44%),差异有统计学意义(P<0.05)。患有甲状腺疾病人群食用含碘食物(主要是海产品)总发生率为76.68%,高于未患有甲状腺疾病人群69.67%,差异有统计学意义(P<0.05)。结论 水源性高碘地区菏泽市牡丹区50岁及以上不同人群中尿碘水平相似,尿碘呈现较高水平(>300μg/L),甲状腺功能异常者以60~69岁人群和女性居多。高碘性水源及含碘食物可能是水源性高碘地区甲状腺疾病的主要危险因素。Objective To investigate the incidence and risk factors of thyroid disease among permanent residents over 50 years old in water-borne high iodine areas in Heze City, and to provide basis for correct guidance and formulation of thyroid disease prevention and control strategies.Methods Randomly selected 9 900 permanent residents aged 50 and above in Mudan District of Heze City, with 4 450 males and 4 450 females, stratified 50-59 years old, 60-69 years old, and 70 years old and above, with 3 300 people each.Questionnaire survey, urine iodine detection, and blood collection to measure serum T_(3),T_(4) and thyroid stimulating hormone(TSH),and thyroid examination.Results The results of serum T_(3),T_(4) and TSH in 60-69 years old were higher than those of 50-59 years old, 70 years old and above.The results of serum T_(3),T_(4) and TSH in female group were higher than those in male group, the differences were statistically significant(P0.05).The levels of urinary iodine in people aged 50-59,60-69,70 and above were(324.92 ±98.49),(337.08 ±101.32) and(343.35±104.08)μg/L,respectively, the differences were no statistically significant(P0.05).The total incidence of abnormal serum T_(3),T_(4) and TSH in 60-69 years old and female population were 5.61% and 6.54%,higher than those of 50-59 years old(3.30%),70 years old and above(4.52%) and male population(1.82%),the differences were statistically significant(P0.05).The total prevalence of thyroid disease in 60-69 years old and female population were 3.15% and 3.64%,higher than those of 50-59 years old(2.39%) and male population(2.67%),the differences were statistically significant(P0.05).The total incidence of goiter in 60-69 years old and female population were 2.15% and 2.27%,higher than 50-59 years old(1.12%),70 years old and above(1.42%)and male population(1.44%),the difference was statistically significant(P0.05).The total incidence of iodized food(mostly seafood) consumption in people with thyroid disease was 76.68%,higher than people without thyroid disease(69.67%)

关 键 词：水源性高碘 甲状腺疾病 流行病学调查 

分 类 号：R591.1[医药卫生—内科学]