Effectiveness and Safety of Chinese Medicine at Shenque(CV 8)for Primary Dysmenorrhea:A Systematic Review and Meta-Analysis of Randomized Controlled Trials  

作　　者：YAN Li-jiao FANG Min ZHU Si-jia WANG Zhi-jie HU Xiao-yang LIANG Shi-bing WANG Dou YANG Dan SHEN Chen Nicola Robinson LIU Jian-ping 

机构地区：[1]Centre for Evidence-Based Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China [2]Department of Oncology,Shanxi Provincial Hospital of Traditional Chinese Medicine,Taiyuan 030012,China [3]Primary Care and Population Sciences,Faculty of Medicine,University of Southampton,SO165ST,United Kingdom [4]Research Design Service South Central,National Institute of Health Research,Southampton,SO166YD,United Kingdom [5]Department of Nursing,Beijing Friendship Hospital,Beijing 100050,China [6]School of Nursing,Beijing University of Chinese Medicine,Beijing 100029,China [7]Institute of Health and Social Care,London South Bank University,London,SE10AA,United Kingdom

出　　处：《Chinese Journal of Integrative Medicine》2023年第4期341-352,共12页中国结合医学杂志（英文版）

基　　金：Supported by Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-C-202006);Longitudinal Development Funding of Beijing University of Chinese Medicine(No.2021-ZXFZJJ-016);the National Institute for Health Research(No.SPCR-143);Shanxi Provincial Health Commission Project(No.2020050)。

摘　　要：Background:Primary dysmenorrhea(PD)is the most common complaint associated with menstruation and affects up to three-quarters of women at some stage of their reproductive life.In Chinese medicine,navel therapy,treatment provided at Shenque(CV 8),is used as a treatment option for PD.Objective:To evaluate the effect of navel therapy on pain relief and quality of life in women with PD,compared with Western medicine(WM).Methods:China National Knowledge Infrastructure(CNKI),Chinese Scientific Journal Database(VIP),Sino Med and Wanfang Database,MEDLINE,the Cochrane Library,Embase,Web of Science,and the International Clinical Trial Registry of the U.S.National Institutes of Health were searched from their inceptions to April 1,2021.Randomized controlled trials(RCTs)assessing therapeutic effects of navel therapy on PD were eligible for inclusion.Rev Man 5.4 software was used for data analyses.The certainty of the evidence was assessed using the online GRADEpro tool.Results:Totally 24 RCTs involving 2,614 participants were identified.Interventions applied to acupuncture point CV 8 included:herbal patching,moxibustion or combined navel therapy(using at least 2 types of stimulation).Compared to placebo,there was a significant effect in favor of navel therapy on reducing overall menstrual symptom scores at the end of treatment[mean difference:-0.82,95%confidence interval(CI):-1.00 to-0.64,n=90;1 RCT].As compared with Western medicine,navel therapy had a superior effect on pain intensity as assessed by Visual Analogue Scale at the end of treatment[standardized mean difference(SMD):-0.64,95%CI:-1.22 to-0.06,I^(2)=80%,n=262;3 RCTs];on symptom resolution rate at 3-month follow-up(risk ratio:1.94,95%CI:1.47 to 2.56,n=1527,I^(2)=38%;13 RCTs);and on global menstrual symptoms score at the end of treatment(SMD:-0.67,95%CI:-0.90 to-0.45,I^(2)=63%,n=990;12 RCTs).Subgroup analyses showed either a better or an equivalent effect comparing navel therapy with Western medicine.No major adverse events were reported.The methodological quality

关 键 词：navel therapy SHENQUE primary dysmenorrhea quality of life systematic review META-ANALYSIS 

分 类 号：R271.113[医药卫生—中医妇科学]