辅助助孕与自然受孕新生儿的临床结局分析  

Clinical outcome analysis of assisted fertility versus naturally conceived newborns

作　　者：郭艳梅 王琍琍[1] 王杨[1] 吴德[1] 崔珍珍 GUO Yanmei;WANG Lili;WANG Yang;WU De;CUI Zhenzhen(Department of Pediatric,The First Affiliated Hospital of Anhui Medical University,Hefei 230000,China)

机构地区：[1]安徽医科大学第一附属医院儿科,安徽合肥230032

出　　处：《西部医学》2023年第5期692-696,共5页Medical Journal of West China

基　　金：国家自然科学基金项目(81472167)。

摘　　要：目的比较辅助助孕与自然受孕新生儿的临床结局及其孕母妊娠期合并症的发生情况,进而为临床早预防、早诊断和早治疗各种并发症提供依据。方法回顾性纳入2019年6月—2020年6月在本院新生儿科住院的188例辅助助孕新生儿为观察组,并随机纳入同期174例自然受孕新生儿为对照组,比较两组新生儿的生长发育及新生儿疾病的发生情况,并分析两组新生儿孕母妊娠期合并症的发生率,同时进行试管组单、双胎间及两组单胎间的临床对比分析。结果观察组孕母的剖宫产率、产前应用激素、合并妊娠期高血压及妊娠期甲状腺功能减退症的发生率均高于对照组(均P<0.05),且观察组内单胎组孕母妊娠期剖宫产率、产前应用激素及合并妊娠期高血压的发生低于双胎组(均P<0.05)。观察组新生儿的出生体重及Apgar评分均低于对照组(均P<0.05),但两组单胎间差异无统计学意义(均P>0.05),而观察组内单胎新生儿的出生体重及Apgar评分均高于双胎新生儿(均P<0.05)。观察组新生儿发生早产、低出生体重、肺炎、新生儿高胆红素血症的比例高于对照组(均P<0.05);同时控制混杂因素孕母年龄后,观察组新生儿发生肺炎、新生儿高胆红素血症的比例仍高于对照组。观察组中单胎试管婴儿早产儿率及肺炎发生率均高于单胎对照组新生儿(均P<0.05);观察组内单胎新生儿早产儿率低于双胎新生儿(P<0.05)。结论辅助生殖技术会增加孕母发生妊娠期高血压、妊娠期甲状腺功能减退症、剖宫产及产前使用激素的风险,辅助助孕较自然受孕新生儿发生早产、低出生体重、肺炎、新生儿高胆红素血症的比例较高,值得临床重视,试管单胎可相应的减少新生儿早产和低出生体重及孕母妊娠期合并症。Objective To compare the clinical outcomes of assisted fertility versus naturally conceived newborns and the occurrence of pregnancy complications during pregnancy,so as to provide evidence for clinical early prevention,early diagnosis and early treatment of various complications.Methods A total of 188 neonates with assisted pregnancy admitted to the neonatology department of our Hospital from June 2019 to June 2020 were retrospectively included as the observation group,and 174 neonates with natural conception during the same period were randomly included as the control group.The growth and development of neonates in the two groups and the occurrence of neonatal diseases were compared,and the incidence of complications during pregnancy in the two groups were analyzed.At the same time,the clinical comparative analysis between single and twins in observation group and between the two groups were compared.Results Prenatal application hormone,cesarean section rate with hypertension during pregnancy and the incidence of hypothyroidism during pregnancy in observation group were higher than in control group(P<0.05).Observation group within single fetal pregnant mother pregnancy cesarean delivery rate,prenatal application hormone and merger of hypertension during pregnancy is lower than the twins group(P<0.05).Neonatal birth weight,and Apgar score of observation group were lower than control group(P<0.05),but there was no statistically significant difference between the two groups of singletons(P>0.05),while the observation group in single fetal neonatal birth weight,and Apgar score were higher than twins newborns(P<0.05).Observation group of preterm delivery and low birth weight,pneumonia,neonatal high bilirubin concentration ratio is higher than the control group(P<0.05).At the same time,the incidence of pneumonia and hyperbilirubinemia in neonates in the observation group was still higher than that in the control group after controlling for maternal age as confounding factors.Singletons test-tube baby infants in obser

关 键 词：辅助助孕新生儿 自然受孕新生儿 围生期疾病 临床结局 妊娠期并发症 

分 类 号：R321-33[医药卫生—人体解剖和组织胚胎学] R722[医药卫生—基础医学]