低量人血白蛋白输注联合营养干预治疗晚发型中重度卵巢过度刺激综合征  

Efficacy of low-dose human serum albumin infusion combined with nutritional intervention in the treatment of late-onset moderate to severe ovarian hyperstimulation syndrome

作　　者：胡玥玥 孙志丰 田鎏 叶艳琴 张颖 张昌军 HU Yueyue;SUN Zhifeng;TIAN Liu;YE Yanqin;ZHANG Ying;ZHANG Changjun(Reproductive Medicine Center,The People's Hospital Affiliated to Hubei University of Medicine,Shiyan 442000,Hubei,China;School of Biomedical Engineering,Hubei University of Medicine,Shiyan 442000,Hubei,China;Hubei Reproductive Medicine Clinical Medical Research Center,Shiyan 442000,Hubei,China;Institute of Biomedical Development,Hubei University of Medicine,Shiyan 442000,Hubei,China)

机构地区：[1]十堰市人民医院•湖北医药学院附属人民医院生殖医学中心,湖北十堰442000 [2]湖北医药学院生物医学工程学院,湖北十堰442000 [3]湖北省生殖医学临床医学研究中心,湖北十堰442000 [4]湖北医药学院生物医药发展研究院,湖北十堰442000

出　　处：《西部医学》2023年第5期706-710,共5页Medical Journal of West China

基　　金：湖北省自然科学基金(2020CFA021)。

摘　　要：目的探讨低量人血白蛋白输注联合营养干预治疗晚发型中重度卵巢过度刺激综合征(OHSS)的效果。方法回顾性分析2014年1月—2018年12月在十堰市人民医院生殖医学中心住院治疗的晚发型中重度OHSS患者69例,使用低量人血白蛋白输注联合营养干预治疗为观察组,大量人血白蛋白输注治疗为对照组。比较两组患者白细胞、红细胞压积、血清白蛋白、血清总蛋白,输注人血白蛋白总量,住院天数,随访妊娠结局。结果观察组血常规中最高白细胞与对照组比较,差异有统计学意义(P<0.05)。观察组输注人血白蛋白总量、住院天数、腹穿次数、出院前红细胞压积与对照组比较,差异有统计学意义(P<0.01),观察组出院前血清白蛋白与对照组比较差异有统计学意义(P<0.05)。两组妊娠结局多胎率、流产率、早产率、活产率、胎儿低出生体重率比较差异无统计学意义(P>0.05)。结论对于晚发型中重度OHSS患者,低量人血白蛋白输注联合营养干预可缩短患者病程,减少住院时间和花费,患者症状较快改善,具有较高的临床推广应用价值。Objective To investigate the effect of low-dose human serum albumin infusion combined with nutritional intervention in the treatment of late-onset moderate to severe ovarian hyperstimulation syndrome(OHSS).Methods The clinical data of 69 patients with late-onset moderate to severe OHSS who were hospitalized in our hospital from January 2014 to December 2018 were retrospectively analyzed.The low-dose human albumin infusion combined with nutritional intervention was used as the observation group,and the massive human albumin infusion group was used as the control group.The blood routine white blood cells,hematocrit,serum albumin,serum total protein,the total amount of human albumin infusion,the length of hospital stay,and the pregnancy outcome were compared between the two groups.Results There was a significant difference between the observation group and the control group(P<0.05).Compared with the control group,the total amount of human albumin,length of hospital stay,frequency of abdominal puncture and hematocrit before discharge in the observation group were significantly different(P<0.01),serum albumin before discharge was significantly different from that of the control group(P<0.05).There were no significant differences in the multiple pregnancy rate,abortion rate,premature birth rate,live birth rate and fetal birth weight between the two groups(P>0.05).Conclusion For late-onset moderate to severe OHSS patients,low amount of human albumin infusion combined with nutritional intervention can shorten the course of disease,reduce the length and cost of hospital stay,and improve the symptoms of patients quickly,which has a high clinical value of promotion and application.

关 键 词：卵巢过度刺激综合征 人血白蛋白 营养干预 治疗 晚发型 

分 类 号：R711.75[医药卫生—妇产科学]