新生儿缺血缺氧性脑病患儿cTnI、CK-MB、IL-6及hs-CRP表达水平及意义  

Expression levels and significance of cTnI,CK-MB,IL-6 and hs-CRP in children with neonatal hypoxic-ischemic encephalopathy

作　　者：雷玉琳[1] 冯琴 熊伶俐 刘翠兰[1] 魏春艳 王泽贞 LEI Yulin;FENG Qin;XIONG Lingli;LIU Cuilan;WEI Chunyan;WANG Zezhen(Department of Neonatology,Guang'an People's Hospital,Guang'an 638000,Sichuan,China)

机构地区：[1]广安市人民医院新生儿科,四川广安638000

出　　处：《西部医学》2023年第5期745-749,共5页Medical Journal of West China

基　　金：四川省卫计委科研课题(17PJ090)。

摘　　要：目的探讨新生儿缺血缺氧性脑病(HIE)患儿心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)、白细胞介素-6(IL-6)及超敏C-反应蛋白(hs-CRP)表达水平及意义。方法选取2019年2月—2021年11月本院收治的90例HIE患儿作为病例组,另选取同期健康体检新生儿66例作为对照组,采用酶联免疫吸附法(ELISA)检测两组患者血清cTnI、CK-MB、IL-6及hs-CRP水平,分析cTnI、CK-MB、IL-6、hs-CRP表达差异及其与HIE严重程度和预后的诊断价值。结果重度组患儿血清cTnI、CK-MB、IL-6及hs-CRP水平高于轻度组和中度组(P<0.05);Spearman相关性分析显示,cTnI表达与CK-MB、IL-6及hs-CRP表达呈正相关(P<0.05),CK-MB表达与IL-6、hs-CRP表达呈正相关(P<0.05),IL-6表达与hs-CRP表达呈正相关(P<0.05);预后不良组患儿血清cTnI、CK-MB、IL-6及hs-CRP水平高于预后良好组(P<0.05);ROC曲线分析显示,cTnI、CK-MB、IL-6、hs-CRP联合预测HIE预后的AUC为0.937高于cTnI的0.702、CK-MB的0.831、IL-6的0.774,hs-CRP的0.743(P<0.05)。结论HIE患儿血清cTnI、CK-MB、IL-6及hs-CRP随着病情加剧表达升高,可用于预后诊断。Objective To explore the expression levels and significance of cardiac troponin I(cTnI),creatine kinase isoenzyme(CK-MB),interleukin-6(IL-6)and high-sensitivity C-reactive protein(hs-CRP)in children with neonatal hypoxic-ischemic encephalopathy(HIE).Methods A total of 90 children with HIE were enrolled as case group between from 2019 to November 2021,while other 66 healthy neonates during the same period were enrolled as control group.The levels of serum cTnI,CK-MB,IL-6 and hs-CRP in both groups were detected by enzyme-linked immunosorbent assay(ELISA).Their differences in the two groups,and the diagnostic value for severity and prognosis of HIE were analyzed.Results The levels of serum cTnI,CK-MB,IL-6 and hs-CRP in case group were higher than those in control group(P<0.05),which were higher in severe group than mild group and moderate group(P<0.05).Spearman correlation analysis showed that expression of cTnI was positively correlated with CK-MB,IL-6 and hs-CRP(P<0.05),CK-MB was positively correlated with IL-6 and hs-CRP(P<0.05),and hs-CRP was positively correlated with IL-6(P<0.05).The levels of serum cTnI,CK-MB,IL-6 and hs-CRP in poor prognosis group were higher than those in good prognosis group(P<0.05).ROC curves analysis showed that AUC of cTnI combined with CK-MB,IL-6 and hs-CRP for predicting HIE prognosis was 0.937,greater than that of cTnI,CK-MB,IL-6 and hs-CRP alone(0.702,0.831,0.774,0.743)(P<0.05).Conclusion The expressions of serum cTnI,CK-MB,IL-6 and hs-CRP up-regulate with the aggravation of HIE,which can be applied in prognosis diagnosis.

关 键 词：新生儿缺血缺氧性脑病 心肌肌钙蛋白I 肌酸激酶同工酶 白细胞介素-6 超敏C-反应蛋白 

分 类 号：R272.1[医药卫生—中医儿科学]