依达拉奉注射液联合磺酰脲类降糖药对合并糖尿病的急性缺血性脑卒中治疗效果分析  

Analysis of the Therapeutic Effect of Edaravone Injection Combined with Sulfonylurea Hypoglycemic Agents on the Treatment of Acute Ischemic Stroke in Combined Diabetes Mellitus

作　　者：范亚华 FAN Yahua(Department of Neurology,Jian'ou Municipal Hospital,Jian'ou,Fujian Province,353100 China)

机构地区：[1]建瓯市立医院神经内科,福建建瓯353100

出　　处：《糖尿病新世界》2023年第3期96-99,107,共5页Diabetes New World Magazine

摘　　要：目的探讨依达拉奉联合磺酰脲类降糖药对合并糖尿病的脑卒中治疗效果分析。方法选择2019年1月—2022年1月在福建省建瓯市立医院接受治疗的75例合并糖尿病的脑卒中患者作为研究对象,采用随机数表法分为研究组38例和对照组37例。对照组给予依达拉奉联合阿卡波糖治疗,研究组给予依达拉奉联合磺酰脲类降糖药治疗。比较两组临床疗效、血糖、颈动脉超声、临床评分水平及不良反应发生情况。结果治疗后,两组临床治疗效果比较,差异有统计学意义(P<0.05)。两组治疗前糖代谢水平比较,差异无统计学意义(P>0.05);治疗后,两组FPG、Fins、2 hPG及HbA1c明显降低,且研究组降低较对照组更为显著,差异有统计学意义(P<0.05)。两组治疗前颈动脉超声水平比较,差异无统计学意义(P>0.05);治疗后,两组IMT、Ds、Dd明显降低,且研究组降低较对照组更为显著,差异统计学意义(P<0.05)。两组治疗前临床相关评分比较,差异无统计学意义(P>0.05);治疗后NHISS及MRS明显降低,但研究组降低较对照组更为显著,差异有统计学意义(P<0.05)。两组不良反应恶心呕吐、腹泻、皮疹瘙痒及低血糖发生率比较,差异无统计学意义(P>0.05)。结论依达拉奉联合磺酰脲类降糖药治疗合并糖尿病的脑卒中效果显著,可有效改善患者血糖水平,且安全性较高。Objective To explore the analysis of the therapeutic effect of edaravone combined with sulfonylurea hypoglycemic agents on acute ischemic stroke with combined diabetes mellitus.Methods Seventy-five stroke patients with combined diabetes mellitus treated at Jian'ou Municipal Hospital from January 2019 to January 2022 were selected as the research objects and 38 cases in the study group and 37 cases in the control group were divided by random number table.The control group was treated with edaravone combined with acarbose,and the study group was treated with edaravone combined with sulfonylurea hypoglycemic agents.The clinical efficacy,blood glucose,carotid ultrasound,clinical score level and the occurrence of adverse reactions were compared between the two groups.Results After treatment,the difference in clinical efficacy between the two groups was statistically significant(P<0.05).There was no statistically significant difference in the comparison of glucose metabolism levels before treatment between the two groups(P>0.05);FPG,Fins,2 hPG and HbAlc were significantly reduced of two groups after treatment,and the reduction was more significant in the study group than in the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference in carotid ultrasound levels before treatment between the two groups(P>0.05);after treatment,IMT,Ds,and Dd were significantly reduced of two groups,and the reduction were more significant in the study group than in the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference in clinical correlation scores between the two groups before treatment(P>0.05);the NHISS and MRS were significantly reduced of two groups after treatment,but the reduction in the study group were more significant than those in the control group,the difference was statistically significant(P<0.05).Adverse reactions rates compared in two groups nausea and vomiting,diarrhea,itchy rash and hypoglycemia,an

关 键 词：依达拉奉 磺酰脲类降糖药 脑卒中 血糖 氧化应激 

分 类 号：R4[医药卫生—临床医学]