机构地区:[1]安徽中医药大学第一附属医院风湿科,合肥230031
出 处:《中华中医药杂志》2023年第4期1874-1878,共5页China Journal of Traditional Chinese Medicine and Pharmacy
基 金:国家自然科学基金项目(No.81473672);安徽省高校自然科学研究基金重点项目(No.KJ2020A0395);安徽中医药大学临床科研基金(No.2020yfyzc55)。
摘 要:目的:研究通络温经法熏蒸对肾虚血瘀型强直性脊柱炎(AS)患者疾病活动伴焦虑抑郁的影响。方法:将2019年1月至2021年5月安徽中医药大学第一附属医院的90例肾虚血瘀型AS患者随机分成中温组、高温组和对照组,每组30例。对照组口服柳氮磺吡啶联合塞来昔布,中温组(>36~40℃)和高温组(>40~44℃)加以通络温经法熏蒸,疗程均为4周。比较治疗前后中医证候评分、症状量化评分、VAS疼痛评分、AS病情活动度(ASDAS)、指地距、枕墙距、Schober试验、晨僵时间、血沉(ESR)、C反应蛋白(CRP)、ASAS、健康状况调查问卷(SF-36)评分、抑郁自评量表(SDS)、焦虑自评量表(SAS)的变化程度。结果:中温组和高温组治疗后各项中医证候评分、症状量化评分、VAS疼痛评分、ASDAS评分、指地距、枕墙距、晨僵时间、ESR、CRP、SDS、SAS均显著低于对照组(P<0.05,P<0.01),Schober试验、SF-36均显著高于对照组(P<0.05,P<0.01)。高温组治疗后各项中医证候评分、VAS疼痛评分、ASDAS评分、ESR、CRP均显著低于中温组(P<0.05,P<0.01)。高温组和中温组ASAS20、ASAS50达标显著高于对照组(P<0.05,P<0.01),且高温组高于中温组(P<0.05)。结论:通络温经法熏蒸对AS伴焦虑抑郁临床疗效显著,其中高温组熏蒸更能有效改善中医证候和焦虑抑郁状态,降低疾病活动,提高患者生活质量。Objective:To study the effect of Tongluo Wenjing method fumigation on disease activity accompanied by anxiety and depression in patients with ankylosing spondylitis(AS)syndrome of kidney deficiency and blood stasis.Methods:A total of 90 patients with AS with kidney deficiency and blood stasis from the First Affiliated Hospital of Anhui University of CM from January 2019 to May 2021 were randomly divided into moderate temperature group,high temperature group and control group,with 30 cases each.The control group was given salazopyridine combined with celecoxib,and the medium temperature group(>36~40 C)and high temperature group(>40~44℃)were fumigated with Tongluo Wenjing method.The course of treatment was 4 weeks.TCM syndrome score,symptom quantifiable score,VAS pain score,AS disease activity(ASDAS),finger distance,occipital wall distance,Schober test,morning stiffness time,ESR,C-reactive protein(CRP),ASAS,SF-36 score and depression self-rating scale were compared before and after treatment(SDS)and self-rating Anxiety Scale(SAS).Results:The scores of TCM syndromes,symptom quantifiable scores,VAS pain scores,ASDAS scores,digital ground distance,occipital wall distance,morning stiffness time,ESR,CRP,SDS and SAS in the moderate and high temperature groups were significantly lower than those in the control group after treatment(P<0.05,P<0.01),Schober test and SF-36 were significantly higher than control group(P<0.05,P<0.01),the TCM syndrome scores,VAS scores,ASDAS scores,ESR and CRP in the high-temperature group were significantly lower than those in the moderate temperature group(P<0.05,P<0.01).The standard of ASAS20 and ASAS50 in high-temperature and medium-temperature groups was significantly higher than that in control group(P<0.05,P<0.01),and high temperature group was higher than medium temperature group(P<0.05).Conclusion:Tongluo Wenjing method fumigation has significant clinical effect on AS with anxiety and depression,among which fumigation in the high temperature group can effectively improve TCM syndromes
关 键 词:强直性脊柱炎 通络温经法 中药熏蒸 疾病活动 焦虑 抑郁 临床疗效
分 类 号:R259[医药卫生—中西医结合]
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