2,3-二氢喹唑啉-4(1H)-酮类衍生物的合成研究进展  

Advances in Synthesis of 2,3-Dihydroquinazolin-4(1 H )-One Derivatives

作　　者：张士国 陈霞 漆偲劼 Zhang Shiguo;Chen Xia;Qi Sijie(China Institute of Atomic Energy,Beijing 102413,China)

机构地区：[1]中国原子能科学研究院,北京102413

出　　处：《山东化工》2023年第5期100-104,共5页Shandong Chemical Industry

摘　　要：概述了水溶剂、有机溶剂、离子液体、无溶剂、乙醇/水溶剂中合成2,3-二氢喹唑啉-4(1H)-酮衍生物的研究进展,主要包括以邻氨基苯甲酰胺、醛(或酮)为基础原料的合成途径和以靛红酸酐、胺或铵盐化合物、醛(或酮)为基础原料的合成途径;并从催化剂性能、反应温度、反应时间、目标产物收率、底物适应用性范围等方面对各合成方法进行简述和比较。The research progress in the synthesis of 2,3-dihydroquinazolin-4(1 H)-ketone derivatives in aqueous solvents,organic solvents,ionic liquids,solvo-free solvents,ethanol/water solvents is summarized.The main synthetic pathways include those based on_(2)-aminobenzamide and aldehydes(or ketones)and those based on indiored anhydride,amine or ammonium compounds,aldehydes(or ketones).The synthesis methods were summarized and compared from the aspects of catalyst performance,reaction temperature,reaction time,yield of target product and suitable application range of substrate.

关 键 词：2 3-二氢喹唑啉-4(1H)-酮类衍生物 溶剂 合成 

分 类 号：TQ253.23[化学工程—有机化工]