Stereoselective Synthesis and Immunological Evaluation of Common O-antigen of P. mirabilis OE and P. vulgaris TG103  

作　　者：Xiaopei Wu Jinsheng Lai Kexin Yang Yunxia Xue Jinxi Liao Liming Wang Jian-song Sun Jing Hu Jian Yin Qingju Zhang 

机构地区：[1]National Research Centrefor Carbohydrate Synthesis,Jiangxi Normal University,99 Ziyang Avenue,Nanchang,Jiangxi 330022,China [2]Key Laboratory of Carbohydrate Chemistry and Biotechnology,Ministryof Education,Schoolof Biotechnology and Wuxi School of Medicine,Jiangnan University,Wuxi,Jiangsu 214122,China

出　　处：《Chinese Journal of Chemistry》2023年第5期535-543,共9页中国化学（英文版）

基　　金：This work was financially supported by the National Natural Science Foundation of China(22167015,22077052,22177041,21977039);Science and Technology Department of Jiangxi Province(jxsq2020101084).

摘　　要：Proteus species especially Proteus mirabilis and Proteus vulgaris are zoonotic pathogens which can cause public health disease.Owing to their antibiotic-resistance,developing vaccines against these pathogens is urgently required.Herein,we describe the first synthesis of the common O-antigen of Proteus mirabilis OE and Proteus vulgaris TG 103.

关 键 词：Stereoselective glycosylation Proteus mirabilis OE proteus vulgaris TG 103 Common O-antigen Immunological evaluation Syntheticcarbohydrate-based vaccine Total synthesis 

分 类 号：O62[理学—有机化学]