利用离散选择实验测量血友病患者治疗偏好的研究述评  

Discrete Choice Experiments on Treatment Preferences for Hemophilia Patients: a Literature Review

作　　者：任茹 李顺平 房云海[4] 王立敏[1,2,3] REN Ru(Centre for Health Management and Policy Research,School of Public Health,Cheeloo College of Medicine,Shandong University,Jinan,Shandong,250012,China)

机构地区：[1]山东大学齐鲁医学院公共卫生学院卫生管理与政策研究中心,山东济南250012 [2]国家卫生健康委员会卫生经济与政策研究重点实验室(山东大学),山东济南250012 [3]山东大学健康偏好研究中心,山东济南250012 [4]山东省血液中心,山东济南250000

出　　处：《医学与社会》2023年第5期102-107,共6页Medicine and Society

基　　金：国家自然科学基金资助项目,编号为72174110。

摘　　要：目的:回顾利用离散选择实验测量血友病患者治疗偏好文献,并评估文献的研究质量,为健康管理和临床实践提供参考。方法:在中国知网、万方、PubMed、Web of Science Core Collection和Embase数据库系统检索离散选择实验文献。纳入属性按受益性、风险性、便利性和费用4个维度进行分类,并评估各属性的相对重要性。使用PREFS工具进行文献质量评估。结果:最终纳入12篇文献。便利性、受益性、风险性和费用维度包含属性的数量占比分别为41.7%、29.8%、22.6%和6.0%;在因子和非因子替代治疗中,血友病患者最为偏好的属性,受益性维度和风险性维度占比均最高(33.3%),其次是便利性维度(26.7%),费用维度最低(6.7%)。PREFS工具评估结果显示,纳入文献的研究质量尚可。结论:尽管便利性维度的属性纳入频率最高,但血友病患者更偏好受益性和风险性维度的属性。医疗产品全周期过程与临床实践中应充分考虑患者偏好,从而提高治疗效果。Objectives:To review the literature on using discrete choice experiment(DCE)to understand patient preference for hemophilia therapeutic interventions,to assess the quality of the identified DCE studies,so as to provide implications for health management and clinical practice.Methods:DCE studies were searched by CNKI,Wanfang,PubMed,Web of Science Core Collection,and Embase databases.The attributes of included DCEs were categorized into four groups:clinical benefits,safety,convenience,and cost.The relative importance of attributes was calculated.The purpose,respondents,explanation,findings,and significance(PREFS)checklist was applied to assess the quality of the included DCEs.Results:12 DCEs were included in the review.Attributes categorized as the convenience group accounted for 41.7%of the total attributes,while the proportions of attributes belonging to clinical benefits,safety,and cost were 29.8%,22.6%and 6.0%,respectively.Among DCE studies focusing on factor and non-factor replacement therapies,clinical benefits and safety(33.3%)were the most preferred,followed by convenience(26.7%)and cost(6.7%).The assessment through the PREFS checklist indicated that the overall quality of the included studies was acceptable.Conclusions:Although convenience-related attributes were the most frequently used in previous DCEs,hemophilia patients played more important role in attributes belonging to clinical benefits and safety.Patient preference should be fully considered in medical product lifecycle and clinical practice to improve the clinical efficacy and performance.

关 键 词：血友病患者 治疗偏好 离散选择实验 

分 类 号：R195.4[医药卫生—卫生统计学]