Atoh1调控毛细胞再生与分化的研究进展  

Progress of Research on Atoh1 Dependent Hair Cell Regeneration and Differentiation

作　　者：栾珺 韩锋产[1] LUAN Jun;HAN Fengchan(Department of Biochemistry and Molecular Biology,Binzhou Medical College,Shandong Provincial Key Laboratory for Genetic Ear Diseases,Yantai 264003)

机构地区：[1]滨州医学院生物化学与分子生物学教研室,山东省医药卫生耳科遗传病重点实验室,烟台264003

出　　处：《中华耳科学杂志》2023年第2期254-257,共4页Chinese Journal of Otology

基　　金：国家基金面上项目:81570927,81771020。

摘　　要：哺乳动物耳蜗毛细胞受损后无法再生,从而造成听力障碍。Atoh1是bHLH转录因子家族中的一员,是正性调控毛细胞再生与分化的关键因子之一。研究发现,Atoh1可与其上游调控基因(Eya1、Six1、Sox2)和下游调节基因(Gfi,Pou4f3,Barhl1)协同作用,调节多种细胞信号转导通路(如Notch,Wnt/β-catenin,SHH,FGF等),诱导耳蜗毛细胞再生。干细胞具有分化成毛细胞样细胞的潜能,该过程依赖Atoh1的表达。因此,调控Atoh1依赖性耳祖细胞或干细胞的定向分化,将为毛细胞损害的临床治疗提供新途径。Mature mammals have no ability to regenerate new hair cells when they are damaged,resulting in permanent hearing impairment.The Atoh1gene is a member of the bHLH transcription factor family.It is one of the key factors that positively regulate the regeneration and differentiation of hair cells.Studies have found that Atohl1 mediates the regeneration of hair cells via interacting with upstream(Eya1,Six1,Sox2)and downstream(Gfi,Pou4f3,Barhl1)genes by regulating multiple signaling transduction pathways(Notch,Wnt/β-catenin,SHH,FGF).Stem cells have the potential to differentiate into hair cell-like cells,in an Atoh1expression dependent manner.Therefore,regulation of Atoh1 dependent differentiation from otic progenitor cells or stem cells into hair cells may provide a new strategy or pathway for treatment of hair cell damage-related hearing disorders.

关 键 词：Atoh1 信号转导 毛细胞再生 干细胞 听力障碍 

分 类 号：R764[医药卫生—耳鼻咽喉科]