人巨细胞病毒感染及其在自身免疫性风湿性疾病中的研究现状  

Human cytomegalovirus infection and its research status in autoimmune rheumatic diseases

作　　者：吴军来 董凌莉[1] 陈雨 WU Jun-lai;DONG Ling-li;CHEN Yu(Department of Rheumatology and Immunology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院风湿免疫科,湖北武汉430030

出　　处：《内科急危重症杂志》2023年第2期112-118,共7页Journal of Critical Care In Internal Medicine

摘　　要：人巨细胞病毒(HCMV)是属于β-疱疹病毒的一种双链DNA病毒,它在感染宿主体内终生潜伏,当宿主免疫功能低下时会再激活。作为一种机会性感染,HCMV抗原被认为是诱发自身免疫反应的触发因素之一,可导致机体自我耐受破坏和自身抗体的产生。近年来,自身免疫性风湿性疾病(ARDs)患者合并HCMV感染已越来越受到临床医师的重视。我们系统回顾了HCMV感染的发病机制、检测方法及治疗经验,以及ARDs患者合并HCMV感染的流行病学、临床表现、危险因素及预后影响因素,旨在为早期识别ARDs患者合并HCMV感染提供有用信息,以期降低ARDs患者发生HCMV感染的患病风险,进一步改善患者生活质量及其预后。Human cytomegalovirus(HCMV)is a double-stranded DNA virus belonging to theβ-subgroup of the herpesvirus family that remains latent in the infected host throughout life and reactivates when the host is immunocompromised.As an opportunistic infection,HCMV antigens operate as a trigger of inducing autoimmune responses that contribute to the breakdown of self-tolerance and the production of autoantibodies.In recent years,HCMV infection in patients with autoimmune rheumatic diseases(ARDs)has aroused increasing attention from clinicians.In this review,we systematically reviewed the pathogenesis,detection methods,and treatment experience of HCMV infection,as well as the epidemiology,clinical manifestations,risk factors,and prognostic factors of HCMV infection in patients with ARDs,aiming to provide useful information for the early identification of HCMV infection in ARDs patients,with a view to reducing the risk of HCMV infection in patients with ARDs,and further improving the quality of life and prognosis of patients.

关 键 词：自身免疫性风湿性疾病 人巨细胞病毒 临床表现 危险因素 预后 

分 类 号：R593.2[医药卫生—内科学]