外周血Toll样受体4在慢性肾小球肾炎中的表达及其与尿微量白蛋白水平的相关性  

Expression of Peripheral Blood Toll-like Receptor 4 and its Correlation with Urinary Microalbumin Level in Chronic Glomerulonephritis

作　　者：王新献 郭晓霞[1] 朱卫伟[2] WANG Xin-xian;GUO Xiao-xia;ZHU Wei-wei(Department of Clinical Laboratory,Anyang Hospital of Traditional Chinese Medicine,Anyang Henan 455000)

机构地区：[1]河南省安阳市中医院检验科,河南安阳455000 [2]河南省安阳市肿瘤医院检验科,河南安阳455000

出　　处：《医学临床研究》2023年第4期568-570,574,共4页Journal of Clinical Research

摘　　要：【目的】探讨外周血Toll样受体4(TLR4)在慢性肾小球肾炎(CGN)中的表达及其与尿微量白蛋白(UMA)水平等肾功能指标的关系。【方法】安阳市中医院收治的113例CGN患者(观察组),其中轻度肾功能不全者77例(轻度组),中度肾功能不全者24例(中度组),重度肾功能不全者12例(重度组);另选取同时间段医院体检的59例健康者为对照组。比较观察组和对照组外周血TLR4及UMA等肾功能指标的表达情况,分析观察组TLR4与UMA等肾功能指标的相关性。【结果】重度组的CD19^(+)TLR4^(+)细胞、CD3^(+)TLR4^(+)细胞水平均高于中度组和轻度组(P<0.05),中度组的CD19^(+)TLR4^(+)细胞、CD3^(+)TLR4^(+)细胞水平均高于轻度组(P<0.05)。观察组患者CD19^(+)TLR4^(+)细胞、CD3^(+)TLR4^(+)细胞水平均高于对照组(P<0.05)。观察组的UMA、视黄醇结合蛋白(RBP)、转铁蛋白(TRF)、胱抑素C、肌酐、尿素氮、尿酸水平均高于对照组(P<0.05)。Pearson相关性分析显示,观察组患者CD19^(+)TLR4^(+)细胞水平与UMA、RBP、胱抑素C呈正相关(P<0.05),CD3^(+)TLR4^(+)细胞水平与UMA呈正相关(P<0.05)。【结论】CGN患者外周血TLR4异常高表达,且TLR4表达水平与UMA等肾功能指标密切相关,TLR4表达水平越高,CGN患者肾功能越差。【Objective】To investigate the expression of peripheral blood Toll-like receptor 4(TLR4)in chronic glomerulonephritis(CGN)and its relationship with urinary microalbumin(UMA)level.【Methods】A total of 113 CGN patients admitted to Anyang Hospital of Traditional Chinese Medicine,including 77 patients with mild renal insufficiency,24 patients with moderate renal insufficiency and 12 patients with severe renal insufficiency,were enrolled in the observation group.Another 59 healthy volunteers who underwent physical examination in our hospital during the same time period were selected as the control group.The expression of renal function indexes such as TLR4 in peripheral blood and UMA in the observation group and the control group were detected,then the correlation between renal function index TLR4 and UMA in the observation group was analyzed.【Results】The levels of CD19^(+)TLR4^(+)cells and CD3^(+)TLR4^(+)cells in the severe renal insufficiency group were higher than those in the moderate renal insufficiency group and the mild renal insufficiency group(P<0.05).The levels of CD19^(+)TLR4^(+)cells and CD3^(+)TLR4^(+)in the moderate renal insufficiency group were higher than those in the wild renal insufficiency group(P<0.05).The levels of CD19^(+)TLR4^(+)cells and CD3^(+)TLR4^(+)cells in the observation group were higher than those in the control group(P<0.05).The levels of UMA,retinol binding protein(RBP)and transferrin(TRF),cystatin C,creatinine,blood urea nitrogen and uric acid in the observation group were higher than those in the control group(P<0.05).Pearson correlation analysis showed that the level of CD19^(+)TLR4^(+)cells in the observation group was positively correlated with UMA,RBP,and cystatin C(P<0.05),and the level of CD3^(+)TLR4^(+)cells was positively correlated with UMA(P<0.05).【Conclusion】The peripheral blood TLR4 expression of CGN patients is abnormally high,and the expression level of TLR4 is closely related to renal function indicators such as UMA.The higher the expression level of TL

关 键 词：肾小球肾炎 慢性病 Toll样受体4/血液 

分 类 号：R692.31[医药卫生—泌尿科学]