石斛生物碱类成分药理活性及其作用机制研究进展  

Research Progress on Pharmacological Effects and Mechanisms of Alkaloid Components in Dendrobium

作　　者：梁艳田 刘佳萌[2] 鲁为 范蓓 王凤忠[2] LIANG Yan-tian;LIU Jia-meng;LU Wei;FAN Bei;WANG Feng-zhong(College of Pharmacy,Hunan University of Traditional Chinese Medicine,Changsha 410208,China;Key Laboratory of Agro-products Quality and Safety Control in Storage and Transport Process,Ministry of Agriculture and Rural Affairs/Institute of Food Science and Technology,Chinese Academy of Agricultural Sciences,Beijing 100193,China)

机构地区：[1]湖南中医药大学药学院,长沙410208 [2]农业农村部农产品质量安全收贮运管控重点实验室/中国农业科学院农产品加工研究所,北京100193

出　　处：《中国食物与营养》2023年第4期40-47,共8页Food and Nutrition in China

基　　金：中国农业科学院农产品加工研究所创新工程(项目编号:125161015000150013)

摘　　要：目的:总结石斛生物碱类成分如石斛总生物碱、石斛碱、石斛宁等药理活性及其作用机制的研究现状,为石斛的合理开发和临床应用提供科学依据。方法:检索近10年中国知网CNKI数据库及PubMed数据库中石斛生物碱类成分药理活性相关文献,根据活性及机制的不同进行总结归纳。结果:目前石斛生物碱类成分的药理活性研究主要集中于神经保护、改善糖脂代谢、保护肝损伤以及抗肿瘤等方面,具有较好的研究前景和开发应用价值。但作用机制的研究对象多为石斛总生物碱,有关生物碱类单体化合物的研究因受到分离纯化困难和提取率低等因素的制约而相对较少。结论:通过提高石斛生物碱类单体化合物提取率和纯度,加强对石斛药效物质基础及机制途径的研究,可为开发石斛相关新药及保健食品提供科学依据。Objective To summarize the current status of research on the pharmacological substances and mechanisms of alkaloid components in Dendrobium such as total alkaloids of dendrobium,dendrobine,shihunine to provide theoretical references for the further development and clinical application of Dendrobium.Method The references related to the pharmacological activities of alkaloid components in Dendrobium that published in recent 10 years were searched in CNKI and PubMed databases,and were summarized according to the activities and mechanisms.Result At present,the pharmacological activity research of alkaloid components in Dendrobium has mainly focused on neuroprotection,improving glycolipid metabolism,protecting liver injury and anti-tumor that show good research prospects and application value.However,most of those studies were on the total alkaloid contents of dendrobium,the researches of alkaloid monomer in dendrobium were relatively few due to the difficulties on purification and low extraction rate.Conclusion The paper can provide more scientific evidence on developing novel drugs and health foods of Dendrobium,which is important to strengthen the research on pharmacological substances and mechanisms by improving the methods on extraction and purification of alkaloid monomer compounds in Dendrobium.

关 键 词：生物碱 石斛碱 药理活性 神经保护 改善记忆 糖脂代谢 

分 类 号：R285[医药卫生—中药学]