环境因素与男性生殖损害研究进展与展望  

Progress and prospect of environmental factors and male reproductive damage

作　　者：夏彦恺[1] 陈卿[2] XIA Yankai;CHEN Qing(State Key Laboratory of Reproductive Medicine,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu Province,211166;Key Lab of Medical Protection for Electromagnetic Radiation of Ministry of Education,Institute of Toxicology,Faculty of Military Preventive Medicine,Army Medical University(Third Military Medical University),Chongqing,400038,China)

机构地区：[1]南京医科大学生殖医学国家重点实验室,南京医科大学公共卫生学院,南京211166 [2]陆军军医大学(第三军医大学)军事预防医学系毒理学研究所,电磁辐射医学防护教育部重点实验室,重庆400038

出　　处：《陆军军医大学学报》2023年第9期861-868,共8页Journal of Army Medical University

基　　金：国家重点研发计划(2022YFC2702900);国家自然科学基金重点项目(82130097)。

摘　　要：男性生殖损害是我国和国际面临的重大卫生健康挑战。环境因素是当前导致男性生殖损害的重要原因之一。识别这些环境因素,阐明其损伤机制并研发针对性的防治策略,对于维护男性生殖健康,提升国家人口安全具有重要意义。本文概述近期环境因素导致男性生殖损伤相关研究进展:在有害因素识别方面,电磁辐射、新兴环境污染物、新冠病毒等物理、化学和生物因素的男性生殖损害效应正逐步被认识;在生殖损害的发生机制方面,铁死亡、昼夜节律与生物钟、表观遗传与染色质特征以及肠道菌群介导的环境因素致男性生殖损害机制成为新的研究热点。未来本领域将紧跟环境变化新形势,借助基础理论研究新进展及多学科交叉融合,深入探索复杂暴露等关键问题,人群与实验室研究相结合推动研究成果向卫生防控实践转化。Male reproductive damage is a major health challenge China and the world are facing.Environmental factors are one of the most important causes of male reproductive damage.Identifying these environmental factors,elucidating their damage mechanisms and developing targeted prevention and control strategies are of great significances in maintenance of male reproductive health and improvement of national population security.In this article,we summarize the recent progress on male reproductive damage caused by environmental factors.In male-reproductive toxicity,physical,chemical and biological factors,including electromagnetic radiation,emerging environmental contaminants and corona virus disease 2019(COVID-19)etc.,have been recently recognized.On the other hand,ferroptosis,circadian rhythm&circadian clock,epigenetics&chromatin characteristics,as well as microbiota have been noticed to play important roles in the mechanism of the damage caused by environmental factors.In the future,we should focus on the new challenges of environmental changes,make full use of the advances in basic research and interdisciplinary integration,profoundly explore the key issues such as combinative exposure,and promote the transformation of research results into health prevention and control practices by combining population and laboratory research.

关 键 词：环境因素 男性 生殖损害 

分 类 号：R698.2[医药卫生—泌尿科学] R994.6[医药卫生—外科学]