图论分析在系统性红斑狼疮患者脑功能活动变化中的应用研究  

The application of graph theory analysis in the changes of brain functional activity in SLE patients

作　　者：李晓露 夏建国[2] 邹红梅[3] 尹明[4] 周文苏 张鹏 LI Xiao-lu;XIA Jian-guo;ZOU Hong-mei(Graduate School of Dalian Medical University,Dalian 116044,China)

机构地区：[1]大连医科大学研究生院,辽宁116044 [2]江苏省泰州市人民医院影像科,江苏225300 [3]江苏省泰州市人民医院风湿免疫科,江苏225300 [4]江苏省泰州市人民医院超声科,江苏225300

出　　处：《放射学实践》2023年第5期540-546,共7页Radiologic Practice

基　　金：江苏省卫健委科研课题(H2018093);江苏省第五期“333工程”科研项目(BRA2017175)。

摘　　要：目的:通过图论分析来研究系统性红斑狼疮(SLE)患者脑功能网络损害的特征,探讨其与临床指标、神经量表之间的关系。方法:搜集38例女性SLE患者和44例健康对照者的静息态脑影像数据,通过图论分析的方法,比较两组受试者网络拓扑属性之间的差异,并在SLE患者中采用Spearman相关性分析探讨拓扑属性的改变与临床指标、神经量表之间的相关性。结果:在全局水平上,SLE患者组和健康对照组的小世界属性值均大于1,提示两组受试者的脑功能网络均具有小世界属性。与健康对照者相比,SLE患者的特征路径长度增大(t=2.613,P=0.0107),全局效率减低(t=-2.496,P=0.0146),局部效率减低(t=-2.442,P=0.0168)。在局部水平上与健康对照者相比,SLE患者左侧颞横回的节点介数(t=-3.713,Bonferroni校正,校正后P<0.05)、节点效率(t=-3.793,Bonferroni校正,校正后P<0.05)减低。相关性分析结果显示,在SLE患者中,特征路径长度与C4呈正相关(r=0.742,P<0.001);局部效率与MMSE呈正相关(r=0.353,P=0.03),与C4呈负相关(r=-0.424,P=0.008);全局效率与C4呈负相关(r=-0.708,P<0.001);节点介数与IgM呈正相关(r=0.735,P<0.001);节点效率与IgM呈正相关(r=0.543,P<0.001)。结论:SLE患者脑网络的全局指标、局部指标存在异常,且与临床指标、神经量表具有一定相关性,提示SLE患者网络拓扑属性的改变可能作为监测疾病变化的影像学标志物,具有一定临床意义。Objective:This study aimed to investigate the characteristics of brain functional network damage in patients with systemic lupus erythematosus(SLE)using graph theory analysis and explore the relationship between these characteristics and clinical indicators and neurological scales.Methods:The resting-state brain imaging datafrom 38 female SLE patients and 44 healthy controls were collected.The topological properties between two groups were compared by graph theory analysis.The correlations between topological property alterations and the clinical data and the neuropsychological scales were explored in SLE patients.Results:At the global level,the small-world attribute values of SLE patients and healthy controls were greater than 1,suggesting that the brain functional networks of both groups had small-world attribute.SLE patients showed longer characteristic path length(t=2.613,P=0.0107),lower global efficiency(t=-2.496,P=0.0146)and local efficiency(t=-2.442,P=0.0168).At the local level,compared with healthy controls,the nodal betweenness centrality(t=-3.713,bonferroni corrected,P<0.05)and nodal efficiency(t=-3.793,bonferroni corrected,P<0.05)in the left transverse temporal gyrus were reduced in SLE patients.Correlation analysis showed that in SLE patients,there were positive correlation between characteristic path length and C4(r=0.742,P<0.001),local efficiency and MMSE(r=0.353,P=0.03),nodal betweenness centrality and IgM(r=0.735,P<0.001),nodal efficiency and IgM(r=0.543,P<0.001).The global and local efficiency were negatively correlated with C4(r=-0.708,P<0.00;r=-0.424,P=0.008,respectively).Conclusion:The global and local indices ofthe network topology properties in SLE patients were abnormal and were correlated with clinical data and neural scales,which may be used as imaging markers for monitoring disease changes in SLE patients.

关 键 词：系统性红斑狼疮 磁共振成像 静息态功能磁共振 脑网络 图论分析 

分 类 号：R593.24[医药卫生—内科学] R445.2[医药卫生—临床医学]