超声背散射信息熵成像评价脂肪肝的新方法  

A new method for assessing hepatic steatosis using ultrasound backscatter information entropy imaging

作　　者：丁琪瑛[1] 吴水才[2] 崔博翔 赵晶[4] 周著黄[2] DING Qiying;WU Shuicai;TSUI PoHsiang;ZHAO Jing;ZHOU Zhuhuang(Ultrasound Room,University Hospital,Beijing University of Technology,Beijing 100124,China;Faculty of Environment and Life,Beijing University of Technology,Beijing International Science and Technology Cooperation Base for Intelligent Physiological Measurement and Clinical Transformation,Beijing 100124,China;College of Medicine,Chang Gung University,Taoyuan 33302,Taiwan,China;Department of Geriatrics,Third Medical Center,PLA General Hospital,Beijing 100039,China)

机构地区：[1]北京工业大学校医院超声室,北京100124 [2]北京工业大学环境与生命学部,智能化生理测量与临床转化北京市国际科研合作基地,北京100124 [3]台湾长庚大学医学院,中国台湾桃园33302 [4]解放军总医院第三医学中心老年医学科,北京100039

出　　处：《声学技术》2023年第2期224-229,共6页Technical Acoustics

基　　金：国家自然科学基金(11804013,61871005);北京市自然科学基金(4222001)。

摘　　要：提出超声背散射Tsallis信息熵成像评价脂肪肝的新方法。利用滑动窗口法,估算窗口内局部背散射包络信号的Tsallis信息熵参数值,对信息熵参数值矩阵进行扫描变换、颜色映射及感兴趣区域设置,叠加到超声B模式图像,实现Tsallis信息熵成像。分析72名肝脏捐献者和204名患者的超声背散射信号,参考标准分别为磁共振波谱测得的肝脏脂肪分数(Hepatic Fat Fraction,HFF)和肝活检组织学检查测得的脂肪肝程度。对于72名肝脏捐献者,Tsallis信息熵与lg(HFF)的相关系数r=0.67(P<0.0001)。对于204名患者,受试者工作特征曲线下面积分别为0.82、0.88、0.89(≥轻度、≥中度、≥重度),而超声背散射零差K成像分别为0.76、0.82、0.82。超声背散射Tsallis信息熵成像可以直观定征并定量评价脂肪肝的严重程度,其诊断性能优于超声背散射零差K成像,可作为一种超声评价脂肪肝的新方法。A new method using ultrasound backscatter Tsallis information entropy imaging for assessing hepatic steatosis is proposed.By the sliding window method,the Tsallis information entropy parameter values of the local backscatter envelope signal in the window are estimated to obtain the matrix of information entropy parameter values,and then,to perform scan conversion and color mapping,and set the region of interest(ROI).The entropy image within the ROI is superimposed on the ultrasound B-mode image to realize the Tsallis information entropy imaging.Seventy-two liver donors and 204 patients are enrolled.The reference standards are the hepatic fat fraction(HFF)measured by magnetic resonance spectroscopy(MRS)and the grade of fatty liver determined by liver biopsy histology.The 3-MHz ultrasound scans the liver to construct B-mode and Tsallis information entropy images for HFF and fatty liver grade analyses.The receiver operating characteristic(ROC)curve is used to evaluate the diagnostic value of the Tsallis information entropy imaging method.The correlation coefficient between Tsallis information entropy and log10(HFF)is r=0.67.The areas under the ROC curve are 0.82,0.88 and 0.89,respectively for fatty grade≥mild,≥moderate,and≥severe.It is concluded that ultrasound backscatter Tsallis information entropy imaging can quantitatively evaluate the grade of fatty liver.

关 键 词：超声背散射 信息熵 定量超声 脂肪肝 超声组织定征 

分 类 号：TB559[理学—物理]