合成磁共振技术联合T1-MPRAGE序列在帕金森病患者尾状核改变中的探讨  

Synthetic Magnetic Resonance Combined with T1-MPRAGE Sequence in Caudate Nucleus Changes in Patients with Parkinson's Disease

作　　者：马文辉 王云玲[1] 罕迦尔别克·库锟 丁爽[1] 贾文霄[1] MA Wen-hui;WANG Yun-ling;HANJIAERBIEKE·Kukun;DING Shuang;JIA Wen-xiao(MR Room,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,Xinjiang Uyghur Autonomous Region,China)

机构地区：[1]新疆医科大学第一附属医院磁共振室,新疆乌鲁木齐830054

出　　处：《中国CT和MRI杂志》2023年第5期168-170,共3页Chinese Journal of CT and MRI

基　　金：国家自然科学基金(81860301);自治区区域协同创新专项(科技援疆计划)(2020E0275)。

摘　　要：目的 应用合成磁共振技术联合T_(1)-MPRAGE序列分析帕金森病(PD)尾状核体积及弛豫值的改变并探讨其在PD诊断中的价值。方法 对30例PD患者及20例健康对照组(HC)均行合成MRI及T_(1)-MPRAGE序列检查,使用FreeSurfer软件自动分割并提取尾状核体积,勾画感兴趣区(ROI)得到双侧尾状核的T_(1)、T_(2)弛豫值及质子密度(proton density PrD)值,比较PD组与HC组间的差异;分别绘制双侧尾状核T_(1)弛豫值、左侧尾状核PrD值及体积与弛豫值联合的受试者工作特征(ROC)曲线并计算曲线下面积(AUC)。结果 PD组与对照组相比,右侧尾状核体积缩小(P<0.05),双侧尾状核T_(1)弛豫值增高(P<0.05),左侧尾状核PrD值减低(P<0.05);左侧尾状核T_(1)值在PD组与HC组中的诊断效能最高,AUC为0.902,敏感度为0.933,特异度为0.850%。结论 通过合成MRI技术联合T_(1)-MPRAGE序列能观察到PD患者核尾状核体积及弛豫值的改变,可以用于鉴别PD患者与正常人,对于PD的诊断和分析具有一定的参考价值。Objective To study the changes of caudate nucleus volume and relaxation in Parkinson's disease(PD)by using synthetic magnetic resonance technique combined with T_(1)-MPRage sequence.Methods Synthetic MRI and T_(1)-MPRage sequences were performed in 30 PD patients and 20 healthy controls(HC).Caudate nucleus volume was automatically segmented and extracted by FreeSurfer software.The region of interest(ROI)was delineated to obtain the T_(1) and T_(2) relaxation values and proton density(PrD)values of bilateral caudate nuclei,and the differences between PD group and HC group were compared.The subject operating characteristic(ROC)curves were plotted for bilateral caudate nucleus T_(1) relaxation values,left caudate nucleus PrD values and combined volume and relaxation values,respectively,and the area under the curve(AUC)was calculated.Results Compared with the control group,the volume of right caudate nucleus decreased(P<0.05),T_(1) relaxation value of bilateral caudate nucleus increased(P<0.05),and PrD value of left caudate nucleus decreased(P<0.05).T_(1) in the left caudate nucleus had the highest diagnostic efficacy in PD group and HC group,with an AUC of 0.902,a sensitivity of 0.933 and a specificity of 0.850.Conclusions Changes in caudate nucleus volume and relaxation value in PD patients can be observed by using synthetic MRI combined with T_(1)-MPRage,which can be used to differentiate PD patients from normal controls,and has certain reference value for the diagnosis and analysis of PD.

关 键 词：帕金森病 磁共振成像 尾状核 合成磁共振技术 

分 类 号：R445.2[医药卫生—影像医学与核医学] R322.81[医药卫生—诊断学]