uAlb、LDH、血脂在老年2型糖尿病患者中的检验价值研究  

Test Value of UAlb,LDH and Blood Lipid in Elderly Patients with Type 2 Diabetes Mellitus

作　　者：张伟 赵振杰 李德欣 ZHANG Wei;ZHAO Zhenjie;LI Dexin(Department of Laboratory,Beijing Fangshan First Hospital,Beijing,102400 China)

机构地区：[1]北京市房山第一医院检验科,北京102400

出　　处：《糖尿病新世界》2023年第2期65-68,72,共5页Diabetes New World Magazine

摘　　要：目的探析尿白蛋白(uAlb)、乳酸脱氢酶(LDH)和血脂在老年2型糖尿病(type 2 diabetes mellitus,T2DM)患者中的检验价值。方法选取2021年4月—2022年6月北京市房山第一医院就诊的124例老年T2DM患者作为观察组,选择同期健康体检的120名老年群体作为对照组,根据是否伴随并发症对观察组患者分为并发症组(n=39)和未发生组(n=85)。所有研究对象均接受糖化血红蛋白(HbA1c)、uAlb、LDH、总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白胆固醇(HDL-C)检测。分析HbA1c与各指标相关性,并通过ROC曲线计算单一与联合检测诊断效能。结果观察组uAlb、TC、TG水平均高于对照组,LDH、HDL-C水平低于对照组,差异有统计学意义(P<0.05)。124例老年T2DM患者中,并发症发生率为31.45%。并发症组uAlb、TC、TG水平均高于未发生组,LDH、HDL-C水平均低于未发生组,差异有统计学意义(P<0.05)。Spearman结果显示,T2DM患者HbA1c与uAlb、TC、TG呈正相关(r=0.632、0.431、0.325,P<0.05);与LDH、HDL-C呈负相关(r=-0.542、-0.417,P<0.05)。uAlb、LDH、血脂联合检测AUC 0.817(0.798~0.957)均高于单一诊断指标(P<0.05);其敏感度、特异度分别为87%、91%。结论uAlb、LDH、血脂应用于老年T2DM疾病及病情监控效果显著,可较准确识别T2DM患者及并发症发生患者,且联合诊断效能更高。Objective To explore the diagnostic value of urinary albumin(uAlb),lactate dehydrogenase(LDH)and blood lipid in elderly patients with type 2 diabetes mellitus(T2DM).Methods 124 elderly T2DM patients from Beijing Fangshan First Hospital from April 2021 to June 2022 were selected as the observation group,and 120 elderly people who underwent physical examination at the same time were selected as the control group,and divided the patients in the observation group into complication group(n=39)and non-occurrence group(n=85)according to whether there were complications.All subjects were tested for glycated hemoglobin(HbA1c),uAlb,LDH,total cholesterol(TC),triglycerides(TG),high density lipoprotein cholesterol(HDL-C).Analyze the correlation between HbA1c and various indicators,and calculate the single and joint testing diagnostic efficacy through ROC curves.Results uAlb,TC and TG levels in observation group were higher than those in control group,while LDH and HDL-C levels were lower than those in control group,the difference was statistically significant(P<0.05).In 124 elderly patients with T2DM,the complication rate was 31.45%.The levels of uAlb,TC and TG in the complication group were higher than those in the non-occurrence group,while LDH and HDL-C were lower than those in the non-occurrence group,the difference was statistically significant(P<0.05).Spearman results showed that HbA1c was positively correlated with uAlb,TC and TG in T2DM patients(r=0.632,0.431,0.325,P<0.05).It was negatively correlated with LDH and HDL C(r=-0.542,-0.417,P<0.05).The combined joint testing of uAlb,LDH and blood lipids for AUC 0.817(0.798-0.957)was higher than that of single diagnostic index(P<0.05).Its sensitivity and specificity were 87%and 91%.Conclusion The application of uAlb,LDH and lipid in elderly T2DM diseases and disease monitoring has significant effects,can accurately identify T2DM patients and patients with complications,and the combined diagnosis efficiency is higher.

关 键 词：UALB LDH 老年2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]