中老年2型糖尿病肾病(DN)的主要危险因素分析  

Analysis of Main Risk Factors of Type 2 Diabetic Nephropathy(DN)in Middle-aged and Elderly

作　　者：何佩茹 林涛[1] 薛玉仿 HE Peiru;LIN Tao;XUE Yufang(Department of Geriatrics,Nanjing Jiangning Hospital,Nanjing,Jiangsu Province,211100 China;Department of Nutrition,Nanjing Jiangning Hospital,Nanjing,Jiangsu Province,211100 China)

机构地区：[1]江苏省南京市江宁医院老年医学科,江苏南京211100 [2]江苏省南京市江宁医院营养科,江苏南京211100

出　　处：《糖尿病新世界》2023年第2期177-179,183,共4页Diabetes New World Magazine

摘　　要：目的探究分析影响中老年2型糖尿病患者发生糖尿病肾病(diabeticnephropathy,DN)的主要危险因素。方法选取2020年1月—2022年3月在江苏省南京市江宁医院接受治疗的2型糖尿病患者207例,以尿白蛋白/肌酐比值(urinary albumin/creatinine ratio,UACR)作为患者分组依据,分为2型糖尿病并发DN组(UACR≥30 mg/g)76例和2型糖尿病未并发DN组(UACR<30 mg/g)131例,统计分析两组患者DN发生的主要危险因素。结果单因素分析中,两组2型糖尿病患者糖尿病病程、合并高血压、吸烟、饮酒、糖化血红蛋白(glycosylated hemoglobin,Hb Alc)水平、三酰甘油(triacylglycerol,TG)水平比较,差异有统计学意义(P<0.05);经Logistic回归分析结果表明,糖尿病病程≥10年、合并高血压为DN独立危险因素(OR=2.361、3.425,P<0.05)。结论中老年DN的主要危险因素包括糖尿病病程≥10年、合并高血压疾病,在临床治疗中针对病程长、血糖控制效果差、合并高血压的糖尿病患者人群应给予重点关注。Objective To explore and analyze the main risk factors affecting diabetic nephropathy(DN)in middleaged and elderly patients with type 2 diabetes.Methods A total of two hundred and seven patients with type 2 diabetes who received treatment in Nanjing Jiangning Hospital from January 2020 to March 2022 were selected.Urinary albumin/creatinine ratio(UACR)was adopted as the basis for grouping of patients.Type 2 diabetes mellitus complicated with DN group(UACR≥30 mg/g)76 cases.type 2 diabetes without DN group(UACR<30 mg/g)131 cases.The main risk factors of DN in the two groups were analyzed statistically.Results In univariate analysis,diabetes course,combined hypertension,smoking,alcohol consumption,glycosylated hemoglobin(HbAlc)level,and Triacylglycerol(TG)level were compared between the two groups of patients with type 2 diabetes,the difference was statistically significant(P<0.05).The independent risk factors of DN were duration of diabetes≥10 years,hypertension(OR=2.361,3.425,P<0.05).Conclusion The main risk factors of DN in middle-aged and elderly people include diabetes with a course of≥10 years and complicated with hypertension.In clinical treatment,attention should be paid to diabetic patients with a long course of disease,poor blood glucose control effect and complicated with hypertension.

关 键 词：2型糖尿病 糖尿病肾病 危险因素 高血压 糖化血红蛋白 病程 

分 类 号：R587.1[医药卫生—内分泌]