不同营养膳食对单纯性肥胖患者血清胰岛素样生长因子水平与BMI的影响  

Effects of Different Nutritional Diets on Serum Insulin-like Growth Factor Levels and BMI in Patients with Simple Obesity

作　　者：崔含[1] 吴志锋 黄秀娟[1] 祁志云[1] 张秀薇[1] CUI Han;WU Zhifeng;HUANG Xiujuan;QI Zhiyun;ZHANG Xiuwei(Department of Endocrinology,Dongguan People's Hospital,Dongguan,Guangdong Province,523059 China)

机构地区：[1]东莞市人民医院内分泌科,广东东莞523059

出　　处：《中外医疗》2023年第1期27-30,共4页China & Foreign Medical Treatment

基　　金：2019年东莞市社会科技发展(一般)项目(201950715001898)。

摘　　要：目的探讨单纯性肥胖患者经过不同营养膳食的治疗后,血清中胰岛素样生长因子-1(IGF-1)、胰岛素样生长因子结合蛋白1(IGFBP1)和胰岛素样生长因子结合蛋白3(IGFBP3)的表达水平情况变化与体质指数(BMI)之间的关系。方法方便选取2020年3月—2021年4月东莞市人民医院收治的73例单纯性肥胖患者为研究对象,采用随机数表法将其分为高蛋白质膳食组(n=37)及轻断食膳食组(n=36)。每6周随访一次,共随访两次,测量干预前后血清IGF-1、IGFBP1及IGFBP3水平与BMI的变化。结果第一次随访后,两组BMI水平对比,差异有统计学意义(P<0.05);血清IGF-1、IGFBP1、IGFBP3、IGF-1/IGFBP3水平对比,差异无统计学意义(P>0.05)。第二次随访后,两组BMI、IGF-1、IGFBP1、IGFBP3、IGF-1/IGFBP3水平比较,差异无统计学意义(P>0.05)。血清IGF-1、IGFBP1及IGFBP3水平均与BMI呈负相关(r=-0.486、-0.530、-0.324,P<0.05)。结论蛋白质膳食模式及轻断食膳食模式对于单纯性肥胖患者的体重管理均具有效果,在制订针对超重、肥胖人群的相关膳食疗法时,可以在具体的膳食指导建议和目标后给予个体化应用。Objective To explore the relationship between the expression levels of IGF-1,insulin-like growth factors-1(IGF-1),insulin-like growth factor binding protein 1(IGFBP-1),and insulin-like growth factor binding protein 3(IGFBP-3)in serum and body mass index(BMI)in patients with simple obesity after treatment with different nutri⁃tional diets.Methods 73 patients with simple obesity admitted to Dongguan People's Hospital from March 2020 to April 2021 were conveniently selected as the study subjects.They were randomly divided into a high protein diet group(n=37)and a light fasting diet group(n=36)using a random number table method.Follow up every 6 weeks,a total of two visits,to measure the changes in serum IGF-1,IGFBP1,and IGFBP3 levels and BMI before and after inter⁃vention.Results After the first follow-up,there was a statistically significant difference in BMI levels between the two groups(P<0.05);there was no statistically significant difference in serum levels of IGF-1,IGFBP1,IGFBP3,and IGF-1/IGFBP3(P>0.05).After the second follow-up,there was no statistically significant difference in BMI,IGF-1,IGFBP1,IGFBP3,and IGF-1/IGFBP3 levels between the two groups(P>0.05).The levels of serum IGF-1,IGFBP1,and IGFBP3 were negatively correlated with BMI(r=-0.486,-0.530,-0.324,P<0.05).Conclusion The protein diet mode and light fasting diet mode are both effective in weight management for simple obesity patients.When formulat⁃ing relevant dietary therapies for overweight and obese populations,personalized application can be given after specific dietary guidance suggestions and goals.

关 键 词：单纯性肥胖 胰岛素样生长因子 BMI 高蛋白质膳食模式 轻断食膳食模式 

分 类 号：R587[医药卫生—内分泌]