非布司他片治疗痛风伴高尿酸血症的临床研究及其对炎性因子IL-1β和NALP3水平的影响  

Clinical Study of Febuxostat Tablets in the Treatment of Gout with Hyperuricemia and its Effect on the Levels of Inflammatory Factors IL-1βand NALP3

作　　者：李含阳 张玉 于莹 LI Han-yang;ZHANG Yu;YU Ying(Department of Pharmacy,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)

机构地区：[1]佳木斯市中心医院药剂科,黑龙江佳木斯154002

出　　处：《医学信息》2023年第10期124-127,共4页Journal of Medical Information

摘　　要：目的研究非布司他片治疗痛风伴高尿酸血症(HUA)的临床疗效,及其对白细胞介素-1β(IL-1β)和嗜中性白细胞碱性磷酸酶家族3(NALP3)水平的影响。方法纳入2019年12月-2021年10月佳木斯市中心医院收治的60例痛风伴HUA病例,依据随机数字表法分为对照组(30例)和观察组(30例)。对照组给予别嘌呤醇片治疗,观察组应用非布司他片治疗,比较两组临床疗效、血尿酸、血肌酐、炎性因子(IL-1β、NALP3)、不良反应、血尿酸复常率及痛风发作情况。结果观察组治疗有效率高于对照组(P<0.05);两组治疗后血尿酸、血肌酐水平低于治疗前,且观察组血尿酸、血肌酐水平低于对照组(P<0.05);观察组治疗后IL-1β、NALP3水平低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);观察组治疗后血尿酸复常率高于对照组,痛风发作率低于对照组(P<0.05)。结论非布司他片治疗痛风伴HUA疗效确切,可降低患者血尿酸、肌酐、IL-1β及NALP3水平,下调炎性反应趋势,改善其血尿酸复常率及痛风发作情况,安全性佳。Objective To study the clinical efficacy of febuxostat tablets in the treatment of gout with hyperuricemia(HUA)and its effect on the levels of interleukin-1β(IL-1β)and neutrophil alkaline phosphatase family 3(NALP3).Methods Sixty patients with gout and HUA admitted to Jiamusi Central Hospital from December 2019 to October 2021 were included and divided into control group(30 patients)and observation group(30 patients)according to the random number table method.The control group was treated with allopurinol tablets,and the observation group was treated with febuxostat tablets.The clinical efficacy,blood uric acid,serum creatinine,inflammatory factors(IL-1β,NALP3),adverse reactions,blood uric acid normalization rate and gout attack were compared between the two groups.Results The effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the levels of serum uric acid and serum creatinine in the two groups were lower than those before treatment,and the levels of serum uric acid and serum creatinine in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of IL-1βand NALP3 in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The recovery rate of serum uric acid in the observation group was higher than that in the control group after treatment,and the attack rate of gout was lower than that in the control group(P<0.05).Conclusion Febuxostat tablets are effective in the treatment of gout with HUA,which can reduce the levels of serum uric acid,creatinine,IL-1βand NALP3,down-regulate the trend of inflammatory response,improve the recovery rate of serum uric acid and gout attack,with good safety.

关 键 词：痛风 高尿酸血症 非布司他片 别嘌呤醇片 血尿酸 

分 类 号：R589.7[医药卫生—内分泌]