吡嗪酰胺引起结核病患者血尿酸升高的情况及影响因素分析  

Analysis of pyrazinamide induced elevated blood uric acid in tuberculosis patients and its influencing factors

作　　者：李晓霞[1,2] 高德杰 LI Xiaoxia;GAO Dejie(Binzhou Central Hospital,Binzhou Shandong 251700;Binzhou Tuberculosis Hospital,Binzhou Shandong 251700)

机构地区：[1]滨州市中心医院,山东滨州251700 [2]滨州市结核病防治院,山东滨州251700

出　　处：《当代医药论丛》2023年第10期9-11,共3页

摘　　要：目的:探讨吡嗪酰胺引起结核病患者血尿酸升高的情况及相关影响因素。方法:收集2021年10月至2022年10月于滨州市中心医院结核科三病区使用吡嗪酰胺治疗的结核病患者的肾功能报告,记录报告中患者的性别、年龄、体重、身高、体质指数(BMI)以及有无糖尿病等信息,同时记录患者用药前后的血尿酸水平,通过Logistic线性回归分析上述因素对血尿酸的影响。结果:本时间段该病区共收治结核病患者122例,其中有男性84例(68.85%),女性38例(31.15%);患者的年龄为15~79岁,其中≤33岁者共有43例(35.25%),>33岁者共有79例(64.75%);患者的体重为33~90 kg,其中<50 kg者共有18例(14.75%),50~75 kg者共有100例(81.97%),>75 kg者共有4例(3.28%);患者的身高为130~187 cm,其中≤170 cm者共有80例(65.57%),>170 cm者共有42例(34.43%);患者的BMI为14.51~32.66,其中≥20者共有61例(50.00%),<20者共有61例(50.00%)。在122例结核病患者中,合并糖尿病者共有19例(15.57%),无糖尿病者共有103例(84.43%)。根据患者性别、年龄(≤33岁、>33岁)、体重(<50 kg、50~75 kg、>75 kg)、身高(≤170 cm、>170 cm)、BMI(≥20、<20)及是否合并糖尿病进行分组,治疗前不同年龄、体重、性别、身高、BMI及糖尿病组之间的血尿酸水平无统计学差异(P>0.05),治疗后各组之间血尿酸水平具有显著统计学差异(P<0.05)。Logistic线性回归分析表明,体重、身高及BMI是血尿酸升高的影响因素,身高与血尿酸水平呈负相关,体重和BMI与血尿酸水平呈正相关,数据差异有统计学意义(P<0.05)。结论:对于使用吡嗪酰胺治疗的结核病患者来说,体重、身高及BMI是其血尿酸升高的影响因素,身高越低、体重越大及BMI越高,则患者的血尿酸水平就越高。Objective:To investigate the elevated blood uric acid in tuberculosis patients caused by pyrazinamide and related influencing factors.Method:Renal function reports of TB patients treated with pyrazinamide in the third section of the tuberculosis Department of Binzhou Central Hospital from October 2021 to October 2022 were collected.Gender,age,weight,height,body mass index(BMI),diabetes and other information of the patients were recorded in the reports.Meanwhile,blood uric acid level of the patients before and after medication was recorded.The influence of above factors on blood uric acid was analyzed by Logistic linear regression.Results:A total of 122 TB patients were admitted to the ward during this period,including 84 males(68.85%)and 38 females(31.15%).Patients ranged in age from 15 to 79 years old,including 43 cases(35.25%)≤33 years old and 79 cases(64.75%)>33 years old.The body weight of the patients was 33~90 kg,of which 18 patients(14.75%)were<50 kg,100 patients(81.97%)were 50~75 kg,and 4 patients(3.28%)were>75 kg.T he height of the patients ranged from 130 cm to 187 cm,of which 80 cas es(65.57%)were≤170 cm and 42 cases(34.43%)were>170 cm.The BMI of the patients ranged from 14.51 to 32.66,of which 61 cases(50.00%)were≥20 and 61 cases(50.00%)were<20.Among 122 TB patients,19(15.57%)had diabetes and 103(84.43%)had no diabetes.Patients were grouped according to gender,age(≤33 years,>33 years),body weight(<50 kg,50~75 kg,>75 kg),height(≤170 cm,>170 cm),BMI(≥20,<20)and whether they had diabetes mellitus.There were no statistically significant differences in blood uric acid level among different age,weight,gender,height,BMI and diabetes groups before treatment(P>0.05),but there were statistically significant differences in blood uric acid level among all groups after treatment(P<0.05).Logistic linear regression analysis showed that weight,height and BMI were the factors influencing the increase of blood uric acid,height was negatively correlated with blood uric acid level,weight and BMI were positive

关 键 词：吡嗪酰胺 结核病 血尿酸 影响因素 

分 类 号：R978.3[医药卫生—药品]