菌群代谢物氧化三甲胺调控畜禽脂肪沉积的研究进展  

Research Progress of Trimethylamine Oxide,a Microbiota Metabolite,on Lipid Metabolism in Livestock and Poultry

作　　者：李万全 查安东 谭碧娥 LI Wanquan;ZHA Andong;TAN Bi'e(College of Animal Science and Technology,Hunan Agricultural University,Hunan Changsha 410128,China;The Institute of Subtropical Agriculture,The Chinese Academy of Sciences,Hunan Changsha 410125,China)

机构地区：[1]湖南农业大学动物科学技术学院,湖南长沙410128 [2]中国科学院亚热带农业生态研究所,湖南长沙410125

出　　处：《中国畜牧杂志》2023年第5期40-47,共8页Chinese Journal of Animal Science

基　　金：国家自然科学基金(U20A2054);财政部和农业农村部:国家生猪产业技术体系(CARS-35)。

摘　　要：氧化三甲胺(TMAO)是肠道菌群衍生代谢物。胆碱、肉碱和甜菜碱经肠道菌群代谢生成三甲胺(TMA)以及氧化三甲胺(TMAO),在畜禽肌肉生长和脂肪沉积调控中发挥重要作用。本文主要综述TMAO生成与肠道菌群之间的关系,探究TMAO影响脂肪沉积的作用机制,以及胆碱、肉碱和甜菜碱对畜禽脂质代谢的影响,为TMAO及其营养前体在畜禽生产上的应用提供参考。Trimethylamine oxide(TMAO)is a kind of microbiota-derived metabolite.Through intestinal flora metabolism,trimethylamine(TMA)and trimethylamine oxide(TMAO)are generated from choline,carnitine,and bataine,which play an important role in skeletal muscle development and fat deposition in livestock and poultry.This review summarizes the relationship between the generation of TMAO and intestinal microbiota,explores the mechanism of TMAO affecting fat deposition,and effects of choline,carnitine and betaine metabolism on lipid metabolism in livestock and poultry,thus providing a reference for the application of TMAO and its nutrient precursors in livestock and poultry production.

关 键 词：胆碱 L-肉碱 甜菜碱 TMAO 肠道微生物 脂质代谢 

分 类 号：S816[农业科学—饲料科学]