生物传热简化模型在冷冻手术中的应用  

Application of Simplified Biological Heat Transfer Model in Cryosurgery

作　　者：田浩[1] 梁航[2] 曹智睿[1] 石启龙 TIAN Hao;LIANG Hang;CAO Zhirui;SHI Qilong(Changchun Institute of Optics,Fine Mechanics and Physics,Chinese Academy of Sciences,Changchun 130033,Jilin,China;The First Bethune Hospital of Jilin University,Changchun 130021,Jilin,China)

机构地区：[1]中国科学院长春光学精密机械与物理研究所,吉林长春130033 [2]吉林大学白求恩第一医院,吉林长春130021

出　　处：《制冷技术》2023年第1期56-63,共8页Chinese Journal of Refrigeration Technology

基　　金：吉林省自然科学基金(No.20200201008JC);中国科学院白求恩医学工程与仪器中心(No.Y92042Y)。

摘　　要：本文采用多项式拟合结合临床实验测试的方法,研究了血液灌注率计算模型的合理简化方法,对简化后的组织血液灌注率计算模型对病灶区生物组织温度场预测精度的影响进行了详细分析。结果表明,当采用肿瘤非冻结区边界温度对血液灌注率计算模型进行简化后,与经典的分段计算模型相比,简化模型对于肿瘤大尺寸血管周围的组织温度计算偏差平均为0.6~2.7℃,与实测值平均偏差1.6~3.8℃,考虑拟合误差和温度分段阙值的不确定性误差,简化模型的最大误差约为2.5~4.0℃,计算精度满足临床要求。通过对若干典型血管构型的家兔气道肿瘤组织进行临床冷冻手术,验证了该简化模型对肿瘤组织温度场的预测精度平均在3℃以内,证明了该简化模型具备指导临床手术的可行性。In this paper,polynomial fitting combined with clinical experimental testing methods is used to study the reasonable simplified method of blood perfusion rate calculation model,and the effect of the simplified tissue blood perfusion rate calculation model on the prediction accuracy of the biological tissue temperature field in the lesion area is analyzed in detail.The results show that when the blood perfusion rate calculation model is simplified by the boundary temperature of the tumor non-freezing zone,compared with the classical segmented calculation model,the simplified model has an average calculation deviation of 0.6-2.7℃for the tissue temperature around the tumor's large blood vessels.The average deviation from the measured value is 1.6-3.8℃.Considering the fitting error and the uncertainty error of the temperature segmentation threshold,the maximum error of the simplified model is about 2.5-4.0℃,and the calculation accuracy meets the clinical requirements.By performing clinical cryosurgery on rabbit airway tumor tissues with typical vascular configurations,it is verified that the simplified model has an average prediction accuracy of tumor tissue temperature field within 3℃,which proves that the simplified model has the feasibility of guiding clinical surgery.

关 键 词：生物传热 肿瘤 血液灌注率 冷冻手术 温度场 

分 类 号：TK124[动力工程及工程热物理—工程热物理] R318.52[动力工程及工程热物理—热能工程]