华西儿童青少年身心健康队列建设概况  

A brief introduction to the construction of West China Children and Adolescents Physical and Mental Cohort

作　　者：盖巧玥 张璐[1] 蔡佳芮 王妤珏 肖成汉[1] 刘振谧[1] GE Qiao-yue;ZHANG Lu;CAI Jia-rui;WANG Yu-jue;XIAO Cheng-han;LIU Zhen-mi(West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu,Sichuan 610041,China)

机构地区：[1]四川大学华西公共卫生学院/四川大学华西第四医院,四川成都610041

出　　处：《现代预防医学》2023年第8期1388-1391,1416,共5页Modern Preventive Medicine

基　　金：四川省自然科学基金(2023NSFSC0652);四川大学专职博士后基金(2022SC012021)。

摘　　要：近年来随着社会经济的快速发展,我国儿童青少年面临诸多身心健康问题。本研究基于华西儿童青少年身心健康队列,整合基因组学、转录组学、蛋白组学、代谢组学等多组学多模态信息,采用关联分析技术,开展从基因、环境到表型的“归因”及“交互”研究,进一步开发风险及预后预测模型,期待精准探究西南部地区儿童青少年重大健康问题的发生发展机制,有效提升该人群健康。本文将从研究目标、内容、优势与不足及进一步展望等4个方面对该亚队列进行简要介绍,重点展现本研究的总体设计。The rapid development of society and economy has caused many physical and mental problems of children and adolescents in China.Based on the West China Children and Adolescents Physical and Mental Cohort,our study integrated information derived from multi-omics and multi-model such as genomics,transcriptomics,proteomics and metabolomics,and also employed association analysis technologies to investigate the causality and interaction between gene,environment and phenotype.Furthermore,we plan to develop a prediction model for risks and prognosis.All together,we expect an accurate exploration of the mechanisms for the occurrence and development of major health problems among children and adolescents in Southwest China,therefore helping improve their health effectively.This article is a brief introduction of mentioned sub-cohort,consisting of 4 sections,aim,content,strength and limitation,with the main aim of presenting the design of the study.

关 键 词：心理健康 儿童 队列研究 

分 类 号：R179[医药卫生—妇幼卫生保健]