多功能铁氧体磁性纳米颗粒表面修饰及生物医学中的研究进展  

Surface modification of multifunctional ferrite magnetic nanoparticles and progress in biomedicine

作　　者：张琳雪 努尔尼沙·阿里甫 兰中文 余忠 李启帆 蒋晓娜 邬传健(综述) 孙科(审校) ZHANG Linxue;ALIFU Nuernisha;LAN Zhongwen;YU Zhong;LI Qifan;JIANG Xiaona;WU Chuanjian;SUN Ke(School of Materials and Energy,University of Electronic Science and Technology of China,Chengdu 610054,P.R.China;School of Medical Engineering and Technology,Xinjiang Medical University,Urumqi 830017,P.R.China)

机构地区：[1]电子科技大学材料与能源学院,成都610054 [2]新疆医科大学医学工程技术学院省部共建中亚高发病成因与防治国家重点实验室,乌鲁木齐830017

出　　处：《生物医学工程学杂志》2023年第2期378-383,共6页Journal of Biomedical Engineering

基　　金：新疆维吾尔自治区自然科学基金项目(2021D01C293);企业委托项目(H04W201146);国家自然科学基金(82202220)。

摘　　要：铁氧体磁性纳米材料(MFNPs)在生物医学领域具有较大应用潜力,如磁共振成像、靶向递药、磁热治疗、基因递送等。MFNPs能够在磁场作用下发生迁移运动,并靶向定位到目标细胞或组织。但是要将MFNPs应用到生物体内,需进一步在MFNPs表面进行修饰。本文对MFNPs常见的修饰方法进行了综述,并总结了它在生物成像、医学检测以及生物治疗等医学领域中的应用,进一步展望了MFNPs的未来应用方向。Magnetic ferrite nanoparticles(MFNPs) have great application potential in biomedical fields such as magnetic resonance imaging, targeted drugs, magnetothermal therapy and gene delivery. MFNPs can migrate under the action of a magnetic field and target specific cells or tissues. However, to apply MFNPs to organisms, further modifications on the surface of MFNPs are required. In this paper, the common modification methods of MFNPs are reviewed, their applications in medical fields such as bioimaging, medical detection, and biotherapy are summarized, and the future application directions of MFNPs are further prospected.

关 键 词：铁氧体 靶向定位 生物成像 生物治疗 

分 类 号：R318.08[医药卫生—生物医学工程]