藤黄化学成分和药理作用的研究进展及其质量标志物(Q-Marker)预测分析  

Research progress on chemical composition and pharmacological effects of gamboge and predictive analysis on quality marker

作　　者：高慧敏 彭代银 王雷 贾步云 彭雷 陈卫东 GAO Hui-min;PENG Dai-yin;WANG Lei;JIA Bu-yun;PENG Lei;CHEN Wei-dong(College of Pharmacy,Anhui University of Chinese Medicine,Hefei 230012,China;Yangtze Delta Drug Advanced Research Institute,Nantong 226133,China;He Rong Jia Pharmaceutical Technology(Nantong)Co.,Ltd.,Nantong 226133,China;MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials,Hefei 230012,China;Institute of Traditional Chinese Medicine Resources Protection and Development,Hefei 230012,China;Anhui Key Laboratory of Chinese Medicinal Formula,Hefei 230012,China;Anhui Key Laboratory of New Manufacturing Technology of Traditional Chinese Medicine Decoction Pieces,Hefei 230012,China)

机构地区：[1]安徽中医药大学药学院,安徽合肥230012 [2]长三角药物高等研究院,江苏南通226133 [3]合荣嘉医药科技(南通)有限公司,江苏南通226133 [4]省部共建安徽道地中药材品质提升协同创新中心,安徽合肥230012 [5]中药资源保护与开发研究所,安徽合肥230012 [6]中药复方安徽省重点实验室,安徽合肥230012 [7]中药饮片制造新技术安徽省重点实验室,安徽合肥230012

出　　处：《中草药》2023年第8期2668-2685,共18页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金面上项目(81773988);国家中医药管理局高水平中医药重点学科《药用植物学》建设项目

摘　　要：藤黄是藤黄科植物藤黄Garcinia hanburyi所分泌的干燥树脂,其化学成分多样,主要包括笼状呫吨酮、五环三萜和植物甾醇,具有抗肿瘤、抗炎、抗菌等药理作用。近年来,研究发现藤黄在抗癌方面有着十分显著的疗效。基于藤黄化学成分和药理作用的研究进展,并根据中药质量标志物理论,从植物亲缘学、化学成分可测性、化学成分有效性、制剂因素的角度进行质量标志物初步预测分析,表明藤黄酸和新藤黄酸可作为藤黄的主要质量标志物,为藤黄质量控制和研究开发提供参考依据。Gamboge is a dry resin secreted by Garcinia hanburyi of Guttiferae family,which has a variety of chemical compositions,mainly including caged xanthone,pentacyclic triterpenoids and phytosterols.It has antitumor,anti-inflammatory,antibacterial and other pharmacological effects.In recent years,studies have found that Gamboge has a very significant effect in anticancer.Based on the research progress of the chemical constituents and pharmacological effects of Gamboge,and according to the theory of quality markers of traditional Chinese medicine,this paper presents a preliminary prediction analysis of its quality markers from the perspectives of plant affinities,chemical composition measurability,chemical composition effectiveness and formulation factors.It was found that gambogic acid and gambogenic acid can be used as the main quality markers of Gamboge,which provide a reference basis for quality control and research development of Gamboge.

关 键 词：藤黄 藤黄酸 新藤黄酸 化学成分 药理作用 抗肿瘤 质量标志物 笼状呫吨酮类 

分 类 号：R286[医药卫生—中药学]