生殖医学中的免疫学临床研究现状  

Current research progress of immunology in clinical reproductive medicine

作　　者：齐新宇[1] 孔菲 赵捷 王海燕[1] 乔杰[1] Xinyu Qi;Fei Kong;Jie Zhao;Haiyan Wang;Jie Qiao(Reproductive Medicine Center,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院生殖医学中心,北京100191

出　　处：《中华妇幼临床医学杂志（电子版）》2023年第1期1-9,共9页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

摘　　要：我国育龄人群不孕症发生率为15%~20%,是不孕症发生率较高的国家之一。人类生殖免疫障碍受多种因素影响,其中免疫因素在临床生殖医学中的作用逐渐被人们熟知。无论是卵母细胞和胚胎质量下降、子宫内膜功能失调或机体环境稳态失衡,均与生殖免疫稳态失调关系密切。深入探索免疫因素在人类生殖免疫障碍性疾病发病中的重要机制,对建立精准、有效的生育障碍诊治新策略,全面提高我国人口生育质量意义重大。笔者拟对生殖医学中的免疫学临床研究的最新进展进行系统阐述,旨在为临床诊治生殖免疫障碍性疾病患者提供帮助。China has a high incidence of infertility affecting 15%-20%reproductive age people.Human reproductive immune disorder is influenced by many factors,and the role of immunity in clinical reproductive medicine is known by people gradually.Poor oocyte and embryo quality,dysfunction of endometrium,and imbalance of organism environment are all closely related to the imbalance between reproductive health and immune homeostasis.Exploring the important mechanism of immune factors in the pathogenesis of reproductive immune disorders is of great significance for establishing accurate and effective new strategies for the diagnosis and treatment of reproductive immune disorders,as well as improving the reproductive quality of our population in an all-round way.In this paper,we will systematically expound the latest research progress of immunology in clinical reproductive treatment in order to provide new insights for clinical diagnosis and treatment of patients with reproductive immune disorders.

关 键 词：生殖免疫 排卵 子宫内膜 炎症 巨噬细胞 生殖免疫障碍 免疫稳态失衡 育龄女性 

分 类 号：R714[医药卫生—妇产科学]