峨眉唐松草的化学成分研究  

Study on chemical constituents of Thalictrum omeiense

作　　者：王晶 张红梅 朱文鹏 彭煜婷 薛春梅 陈昭静 李占林 李达翃 华会明 WANG Jing;ZHANG Hong-mei;ZHU Wen-peng;PENG Yu-ting;XUE Chun-mei;CHEN Zhao-jing;LI Zhan-lin;LI Da-hong;HUA Hui-ming(Key Laboratory of Structure-Based Drug Design and Discovery,Ministry of Education,School of Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China)

机构地区：[1]沈阳药科大学中药学院基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110016

出　　处：《中草药》2023年第7期2028-2035,共8页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82173715)。

摘　　要：目的 对峨眉唐松草Thalictrumomeiense根中的化学成分进行研究。方法 运用硅胶、ODS柱色谱、制备高效液相色谱等分离手段对峨眉唐松草根95%乙醇提取物的化学成分进行分离,采用核磁、质谱等多种波谱技术鉴定化合物结构。结果 从峨眉唐松草根95%乙醇提取物中分离得到了19个化合物,分别鉴定为5S-对羟基苯基乙氧基-吡咯烷-2-酮(1a)和5R-对羟基苯基乙氧基-吡咯烷-2-酮(1b)、discretine(2)、(-)-argemonine(3)、O-methylthalisopavine(4)、magnolamide(5)、马尿酸(6)、氧化小檗碱(7)、polyberbine(8)、O-methylpallidine(9)、(-)-ocobotrine(10)、8,9-dihydroprooxocryptochine(11)、唐松草亭碱(12)、小檗碱(13)、meliasendaninD(14)、(+)-(7R,7′R,8S,8′S)-新橄榄树脂素(15)、(-)-南烛木树脂酚(16)、5′-甲氧基异落叶松脂素(17)、(7R)-7,8-二氢-7-甲氧基松柏醇(18)。结论 化合物1a和1b为新化合物,命名为(-)-峨眉唐松草碱A和(+)-峨眉唐松草碱A;化合物8、9、11、14为首次从唐松草属植物中分离得到。Objective To study the chemical constituents from the roots of Thalictrum omeiense.Methods The 95%ethanol extracts from the roots of T.omeiense was isolated by silica gel,ODS column chromatography and preparative high performance liquid chromatography and other separation techniques.The structures of the compounds were identified by NMR,MS and other spectroscopic techniques.Results Nineteen compounds were isolated from 95%ethanol extract of the roots of T.omeiense and their structures were identified as 5S-and 5R-(p-hydroxyphenylethoxy)-pyrrolidin-2-one(1a,1b),discretine(2),(−)-argemonine(3),O-methylthalisopavine(4),magnolamide(5),hippuric acid(6),oxyberberine(7),polyberbine(8),O-methylpallidine(9),(−)-ocobotrine(10),8,9-dihydroprooxocryptochine(11),thalidastine(12),berberine(13),meliasendanin D(14),(+)-(7R,7′R,8S,8′S)-neoolivil(15),(−)-lyoniresinol(16),(+)-5′-methoxy-isolariciresinol(17)and 7,8-dihydro-(R)-7-methoxyconiferyl alcohol(18).Conclusion Compounds 1a and 1b are new alkaloids named(−)-thalicine A and(+)-thalicine A,and compounds 8,9,11 and 14 are isolated from this genus for the first time.

关 键 词：峨眉唐松草 生物碱 5S-对羟基苯基乙氧基-吡咯烷-2-酮 5R-对羟基苯基乙氧基-吡咯烷-2-酮 峨眉唐松草碱A polyberbine 唐松草亭碱 小檗碱 meliasendanin D 

分 类 号：R284.1[医药卫生—中药学]