肠道菌群失调在消化道肿瘤中的研究进展  

Research progress of intestinal flora imbalance in gastrointestinal tumors

作　　者：王婷[1] 李兴华[1] WANG Ting;LI Xing-hua(Department of Gastroenterology,Shanghai Eighth People's Hospital affiliated to Jiangsu University,Shanghai 200235,China)

机构地区：[1]江苏大学附属上海市第八人民医院消化内科,上海200235

出　　处：《中国病原生物学杂志》2023年第4期495-496,F0003,共3页Journal of Pathogen Biology

摘　　要：肠道菌群失调可经由免疫、基因毒性、代谢异常、脑-肠轴等途径诱导消化道肿瘤(GT)发生及进展。同时,肠道内的双歧杆菌、乳酸菌等有益菌可辅助化学、免疫治疗药物诱导T细胞活化,提高上述药物的抗癌效应。或经由饮食方法,通过调整饮食行为,保持良好的饮食习惯,可对肿瘤治疗起到一定帮助。故充分调节肠道菌群,助力GT的治疗,不仅有利于控制患者病情进展,还能够最大化减轻机体受到的损伤,值得做深入研究。本研究现对肠道菌群的近期研究现况进行了总结,详细阐述了肠道菌群和GT的关系及其在治疗中的积极作用。Intestinal dysbacteriosis can induce the occurrence and progression of gastrointestinal tumors(GT)through immune,genotoxicity,metabolic abnormalities,brain-gut axis and other ways.At the same time,bifidobacteria,lactic acid bacteria and other beneficial bacteria in the intestine can assist chemical and immunotherapeutic drugs to induce T cell activation and improve the anticancer effect of the above drugs.Or adjusting dietary behavior and maintaining good dietary habits through dietary methods can play a certain role in tumor treatment.Therefore,fully regulating intestinal flora and assisting the treatment of GT are not only conducive to controlling the progress of patients'disease,but also can minimize the damage to the body,which is worthy of further research.This study summarizes the recent research status of intestinal microflora and elaborates the relationship between intestinal microflora and GT and its positive role in treatment.

关 键 词：肠道菌群失调 消化道肿瘤 免疫 基因毒性 代谢产物 综述 

分 类 号：R378.2[医药卫生—病原生物学]